Genomics Shared Resource

基因组学共享资源(GSR)是一个核心实验室，自1999年以来一直得到CCSG的部分支持。GSR实验室的目的是在快速发展的基因组分析领域提供专业知识和服务。在目前的赠款期间，GSR已将其服务从基因分型扩大到其他一些基因组分析。目前，GSR提供核酸分离和质量分析、基因分型以及基因表达、拷贝数改变和甲基化分析服务，以支持由夏威夷大学(UH)癌症中心成员进行的同行评审和IRB批准的研究。对癌症生物学研究以及流行病学和临床研究中收集的样本进行了各种分析，这些研究利用了多民族人口，特别是夏威夷人的遗传异质性。这些研究的规模从几个样本到数万个样本不等，重点从单个SNP或基因到整个基因组，每个样本的分析从一种到超过一百万种不等。其目标是将人类基因组中现有的信息转化为关于癌症病因、预防和治疗的新知识。随着几个微阵列平台的增加，GSR大大扩展了其服务范围，并为UH癌症中心和联盟的更多用户(包括基础科学研究人员)提供服务。GSR通过提供使用尖端和高吞吐量技术的中央服务来减少中心的冗余。此外，GSR的人员还可以在项目执行期间提供项目规划建议和故障排除能力。GSR的人员在分子生物学和遗传学领域具有很高的知识水平，可以为新手和高级用户提供夏威夷其他地方找不到的技术支持、咨询和信息服务。

The Genomics Shared Resource (GSR) is a core laboratory that has been supported in part by the CCSG since 1999. The purpose of the GSR laboratory is to provide expertise and services in the fast developing area of genomic analysis. During the current grant period, the GSR has expanded its services from genotyping to a number of other genomic analyses. Currently, the GSR provides nucleic acid isolation and quality analysis, genotyping, and also gene expression, copy number alteration and methylation analysis services in support of the peer-reviewed and IRB-approved research conducted by University of Hawai'i (UH) Cancer Center members. A variety of assays are performed on samples from cancer biology studies as well as on those collected in epidemiological and clinical studies that take advantage of the genetic heterogeneity of multiethnic populations, especially from Hawai'i. The scale of these studies varies from a few to tens of thousands of samples, the focus ranges from a single SNP or gene to genome-wide, and the assays performed on each sample range from one to over a million. The goal is to translate information now available on the human genome into new knowledge about cancer etiology, prevention and treatment. With the addition of several microarray platforms the GSR has significantly extended the range of its services and is serving a larger number of users (including basic science investigators) at UH Cancer Center and The Consortium. The GSR reduces redundancies at the Center by furnishing a central service that uses cutting edge and high-throughput technologies. In addition, the personnel of the GSR can provide project planning advice and troubleshooting capabilities during the execution of the projects. The personnel of the GSR are highly knowledgeable in the areas of molecular biology and genetics, and can provide both the novice and the advanced users with a level of technical support, consultation and information services that are not found elsewhere in Hawai'i.