Clincal and Translational Science Award

国家卫生研究院的临床和翻译科学奖的RFA促进了 学术医疗机构消除将基本发现转化为更好成果的障碍 改善我们公民的健康，并纠正临床和翻译劳动力短缺的问题。该委员会的这项建议 威斯康星州东南部的临床和翻译科学研究所是为满足 并为实现上述目标提供了一种新颖和变革性的计划 目标。在我们地区主要学术和医疗机构之间长期合作的基础上， 我们已经建立了一个独特的学术和社区合作伙伴关系，由威斯康星医学院组成， 威斯康星大学密尔沃基分校、马奎特大学、密尔沃基工程学院、弗罗德特医院、 威斯康星州儿童医院、弗吉尼亚州扎布洛基医疗中心和威斯康星州血液中心，坐落在 具有显著的种族和社会多样性的大型城市社区。我们的建议汇集了各种 伙伴机构的资源，以确定和解决阻碍开展临床和医疗服务的障碍 该地区的翻译研究。我们CTSI的转型环境侧重于相互依赖 和我们研究团队的相互关系，以及关键职能与CTSA其他部门的关系 他们的整合、赋能和影响作用。 为了实现这一转变，我们提出(并已在颁奖前几年开始实施)1) 为临床与转化科学学科建立一个独特的“学术之家”--临床与转化学 翻译科学研究所(CTSI)-超越机构内部和机构间障碍，为 有经验的领导层有权力和资源来促进、促进、协调和促进 从工作台到床边(TL)、到临床实践(T2)和我们的社区的转化性研究的连续统一体 (3)；2)通过创新计划增加参与临床研究的研究人员数量 在CTSI内；3)开发、调整和协调跨机构的基础设施，以提供我们的科学家 拥有临床和转译研究所需的资源；以及4)参与临床实践和 社区参与提高公众健康水平的研究。我们的社区参与计划是MCW的强项。 我们将建立更健康的威斯康星州伙伴计划(HWPP)和专业知识的现有网络，并 我们在医疗、生物医学工程、牙科、护理、社会科学和相关健康领域的合作伙伴的资源 双学科实施新的基于社区(T3)的研究计划。我们相信我们的CTSA模型是 可以转移到全国其他类似规模的学术研究社区。 相关性(请参阅说明)： 迫切需要更好的预防措施、更准确的诊断和更有效的治疗 改善我国公民的健康状况。此应用程序提供了一种新颖而全面的机制来解决 通过研究和教育来满足这些需求。它在威斯康星州东南部创造了一个无边界的协作环境 让生物医学研究人员、医疗保健提供者、教育工作者、公民和行业协同工作 并将这些基本发现转化为我们公民更好的健康。

The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transfonning environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transfonnation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (Tl), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country. RELEVANCE (See instructions): Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.