Institute for Biomedical and Health Disparities Research

该提案的目的是在以前的RCMI支持的基础上，在全国最大的单一校园HBCU德克萨斯南方大学（大津）建立一个生物医学和健康差异研究所。该研究所将继续作为大津州立大学的首要研究基础设施建设实体，并将帮助大津州立大学实现其战略研究愿景，同时满足国家需要，解决和缓解涉及心血管疾病，糖尿病，艾滋病和许多其他疾病的健康差距。该研究所的研究目标是成为一个领导者，并在生物医学和健康差异研究的一个或多个领域获得全国性的突出地位。本申请中提出的基础设施将为大津研究人员提供他们所需的研究资源，以进行重大基础科学发现，这些发现可能导致识别参与疾病过程的新基因或蛋白质。这些发现可能会增加这些研究人员开发新药物和/或系统来诊断，治疗，预防或治愈疾病的潜力。大津大学未来十年的战略研究愿景包括领导提供多样化，高度竞争力和训练有素的生物医学研究人员干部;为生物医学和行为研究提供最先进的研究设施;在生物医学和制药科学方面创建新的研究生学位课程;建造一个新的157，000平方英尺，4000万美元的科学大楼;在大津和其他地方发展高生产力的研究合作;创建多个赋予教授职位和椅子;并在环境毒理学，生物医学或健康差异研究的一个或多个领域获得国家认可。拟建的研究所考虑到了科学研究技术的进步，因此需要大量支持，以使大津快速达到这一水平。为了实现上述目标，并加快发现和研究成果转化为患者，我们建议在生物标志物和生物传感器技术、计算研究、分子生物学和组织工程、蛋白质组学和功能基因组学方面建立核心设施。此外，我们将招聘2名新成立的调查员;继续发展目前RCMI计划下雇用的五名现有教师;开展辅导学生发展计划;将同行评审出版物的平均年度数量从15增加到20;将赠款申请提交的平均数量从28增加到50;将每年由NIH和其他授予机构颁发的竞争性校外生物医学研究奖的数量从16个增加到32个。NCRR对拟议研究所的持续支持将有助于通过提供最先进的基础设施来利用其投资，这将使大津州立大学的研究人员能够与其他机构的科学家竞争，以获得与美国公共卫生署使命相关的生物医学和/或行为研究的支持。通过投资于大津的研究基础设施建设工作，NCRR将在其努力扩大健康科学研究能力和促进国家生物医学研究能力方面拥有一个强有力的合作伙伴。

The purpose of this proposal is to build on previous RCMI support and develop an Institute for Biomedical and Health Disparities Research at the largest single campus HBCU in the nation, Texas Southern University (TSU). The Institute will continue to serve as TSU's premier research infrastructure building entity and will help TSU achieve its strategic research vision, while meeting the national need to address and ease health disparities involving cardiovascular illnesses, diabetes, AIDS, and many other diseases. The Institute's goals for research are to become a leader and gain national prominence in one or more areas of biomedical and health disparities research. The infrastructure proposed in this application will provide TSU researchers with the research resources they need to make major basic science discoveries that may lead to the identification of novel genes or proteins involved in a disease process. These discoveries may increase the potential of these researchers to develop novel drugs and/or systems to diagnose, treat, prevent, or cure a disease. TSU's strategic research vision for the next decade includes leadership in providing a diverse, highly competitive, and welltrained cadre of biomedical researchers; providing state-of-the-art research facilities for the conduct of biomedical and behavioral research; creating new graduate degree programs in the biomedical and pharmaceutical sciences; constructing a new 157,000 square feet, $40 million Science Building; developing highly productive research collaborations at TSU and elsewhere; creating multiple endowed professorships and Chairs; and achieving national recognition in one or more areas of environmental toxicology, biomedical, or health disparities research. The proposed Institute takes into account the advances in scientific research technology, and as such is requesting substantial support that will be needed to fast forward TSU to this level. To achieve the aforementioned goals and to accelerate discovery and translation of research to patients, we propose to create core facilities in biomarker and biosensor technology; computational research; molecular biology and tissue engineering; and proteomics and functional genomics. Further, we will recruit 2 new established investigators; continue to develop the five existing faculty hired under the current RCMI program; conduct a mentored student development program; increase the average annual number of peer-reviewed publications from 15 to 20; increase the average number of grant application submissions from 28 to 50; and double the annual number of competitive extramural biomedical research awards from the NIH and other granting agencies from 16 to 32. NCRR's continued support of the proposed Institute will help to leverage its investment by providing state-of-the-art infrastructure that will enable TSU investigators to compete with scientists at other institutions to obtain support for the conduct of biomedical and/or behavioral research relevant to the mission of the U.S. Public Health Service. By investing in this research infrastructure building effort at TSU, the NCRR will have a strong partner in its effort to expand the capability for research in the health sciences and contribute to national biomedical research capability.