CORE BIOLOGY AND SYNTHESIS FACILITIES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该中心认为，核心设施的活动对其科学研究的成功至关重要 和人力资源发展目标。主要目标是维持 核心生物学设施，并建立最先进的核心合成设施，将影响 在南洋理工大学和其他地方进行研究。这些设施将为研究人员提供培训、咨询 在实验设计中，并作为设备的资源。中国的合格人员 这些核心设施将协助初级调查人员，并将在协助其他 北达科他州NDSU的研究人员和教职员工。 核心生物学设施成立于2003年。它由三个部分组成：组织 培养，分子生物学和生物分析，并提供培训和使用的设备和 给研究人员的试剂。此外，实验室还配备了执行常规工作的人员 生物检测和体外生物检测。该设施定期执行基本测试，以 由最初的Cobre研究人员设计的基质金属蛋白酶和HDAC抑制剂的疗效。 建立合成核心的目的是通过为研究工具提供小有机分子来帮助所有生物医学研究人员，并增加该中心目前药物发现工作的吞吐量。能够快速、并行地合成一种先导化合物的许多类似物的设备对于理解结构、活性关系和开发新的方向至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Center views the activities of the core facilities to be central to the success of its scientific and human resource development goals. The main objectives are to maintain the activity of the Core Biology Facility and establish a state-of-the-art Core Synthetic Facility that will impact research at NDSU and beyond. These facilities will provide training for researchers, consultation in experimental design, and function as a resource for equipment. The qualified personnel in these core facilities will assist junior investigators and will also play a key role in assisting other NDSU researchers and faculty in the state of North Dakota. The Core Biology Facility was established in 2003. It is comprised of three components: Tissue Culture, Molecular Biology, and Bioassays, and offers training and use of equipment and reagents to researchers. Additionally, the lab is staffed with personnel to perform routine bioassays and in vitro biological assays. The facility routinely performs the essential testing for the efficacy of the MMP and HDAC inhibitors designed by the original COBRE investigators. The establishment of a Synthetic core is intended to aid all biomedical researchers by providing small organic molecules for research tools and to increase the throughput of current drug discovery endeavors in the Center. A facility that can provide rapid and parallel synthesis of many analogs of a lead compound is crucial for understanding structure activity relationships and developing new directions.