Basic Research Center on Molecular and Cell Biology of Drug Abuse

药物成瘾分子和细胞生物学基础研究中心（MCBDA）成立于10年前，其目标是：（1）促进药物成瘾研究的跨学科方法;（2）作为一个“活动”中心，协调和促进明尼苏达大学药物成瘾研究的所有学术和学术活动;（3）作为药物成瘾研究的分子和细胞生物学的国家资源：（4）作为明尼苏达大学年轻科学家的培训中心。该中心由8个科学组成部分组成，使用多学科方法研究药物成瘾的分子机制。中心的活动包括主办研讨会和一年两次的专题讨论会，提高了明尼苏达大学吸毒成瘾研究的知名度，并为中心成员和非成员之间的互动提供了机会。该中心已成为药物成瘾研究的试剂、质粒构建体、病毒和基因改变小鼠的国家和国际来源。该中心已被证明是一个很好的培训基地，在明尼苏达大学，国内和国际调查。通过在上一个资助期内启动的种子赠款计划，我们为研究人员提供了探索药物成瘾研究创新方法的机会。种子赠款还提供了机会，招募新的调查人员进入吸毒成瘾领域。我们希望在过去成功的基础上再接再厉，在下一个资助期继续中心的使命。我们的研究主题将集中在阿片类药物作用和成瘾的分子和细胞生物学。为了进一步促进科学组成部分之间的协同作用，我们将重新建立分子细胞和遗传核心。因此，该中心的拟议结构将由5个科学组成部分组成，并由一个行政核心和一个服务核心提供支持。坚持我们的目标，招募和促进药物成瘾研究的年轻研究人员的发展，我们将继续我们成功的种子赠款计划，也将启动一个新的试点项目计划，招募和发展的年轻研究人员谁可以有助于中心的使命。科学部分的主要调查人员展示了以往合作的记录，并致力于中心的使命。我们将通过参与现有的社区外展计划来提高吸毒成瘾的可见度，并与明尼苏达大学医学院的临床医生建立联系。与其他中心的方案一起，该中心将继续成为了解吸毒成瘾的分子和细胞机制的研究培训中心和国家资源。

The Basic Research Center on Molecular and Cell Biology of Drug Addiction (MCBDA) was established 10 years ago with the objectives to (1) to foster interdisciplinary approaches in drug addiction research; (2) to serve as an "activity" center to coordinate and to promote all academic and scholarly activities on drug addiction research at University of Minnesota; (3) to serve as a national resource for molecular and cell biology of drug addiction research: and (4) to serve as training center for young scientists here at University of Minnesota. The Center was founded with 8 scientific components that use multidisciplinary approaches in their investigation of molecular mechanisms of drug addiction. Center activities have included sponsored seminars and biannual symposium, which have raised the visibility of drug addiction research at the University of Minnesota and provided opportunities for interactions among Center members and nonmembers. The Center has served as a national and international source of reagents, plasmid constructs, viruses and genetically altered mice for drug addiction research. The Center has proven to be an excellent training ground for investigators at the University of Minnesota, nationally and internationally. Through the Seed Grants Program initiated during last funding period, we have provided opportunities for investigators to explore innovative approaches for drug addiction research. The seed grants also provided opportunities to recruit new investigators into drug addiction field. We wish to build on the past success and continue the missions of the Center in the next funding period. Our research theme will focus on the molecular and cell biology of opioid actions and addiction. In order to further foster the synergistic interactions among the scientific components, we will re-establish the Molecular Cellular and Genetic Core. Thus, the proposed structure of the Center will consist of 5 scientific components supported by an administrative core and a service core. Adhering to our goal to recruit and foster development of young investigators in drug addiction research, we will continue our successful Seed Grant Program and also will initiate a new Pilot Project Program for the recruitment and development of young investigators who could contribute to the mission of the Center. The principle investigators of the scientific components have demonstrated records of past collaboration and are committed to the mission of the Center. We will raise the visibility of drug addiction by participating in the existing community outreach programs, and initiate contacts with the clinicians at the University of Minnesota Medical School. Together with the other Centers' programs, the Center will continue to be a research training center and national resource on the understanding of the molecular and cellular mechanism of drug addiction.