2012 Ligand Recognition and Molecular Gating Gordon Research Conference

Gordon Research Conference on Ligand Recognition and Molecular Gating将于2012年1月15日至20日在加利福尼亚州文图拉举行。会议的广泛和长期目标是增加我们对膜蛋白如何结合或识别配体（离子，小分子，蛋白质）并跨膜传输信号的理解。会议的主要目的是分享关于离子通道，G蛋白偶联受体和所有类型转运蛋白的最新知识，重点是将高分辨率结构数据与功能信息相结合，以了解机制。这三种不同类型的膜蛋白的统一主题是配体结合、门控和/或转运涉及构象变化。确定的，机械相关的构象的全功能蛋白质的表征将是2012年会议的重点。该计划将有大约40名发言人，在膜蛋白研究领域的知名领导者以及有前途的年轻研究人员。九个会议将广泛讨论参与感觉转导的离子通道、钾通道和谷氨酸受体通道、二级转运蛋白、ATP驱动的转运蛋白、2-肾上腺素能受体、多巴胺受体和其他GPCR的结构和机制。还将有关于膜蛋白结构生物学和脂质-蛋白质相互作用的新方法的会议。配体识别和分子门控的戈登研究会议的目标是通过汇集该社区中一些最重要的科学家来展示和比较结果，讨论新的想法并建立合作来刺激膜蛋白研究这一领域的进展。

DESCRIPTION: The Gordon Research Conference on Ligand Recognition and Molecular Gating will be held on Jan 15 - 20, 2012, in Ventura, CA. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins) and transmit signals across membranes. The main objective of the conference is to share the newest knowledge on ion channels, G protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional information to understand mechanisms. A unifying theme in these three different classes of membrane proteins is that ligand binding, gating, and/or transport involves conformational changes. The characterization of defined, mechanistically relevant conformations of fully functional protein will be a focus of the 2012 conference. The program will have about 40 speakers, well-established leaders in the field of membrane protein research as well as promising young investigators. Nine sessions will broadly address structure and mechanism of ion channels involved in sensory transduction, potassium channels and glutamate receptor channels, secondary transporters, ATP-driven transporters, 2-adrenergic receptors, dopamine receptors and other GPCRs. There will also be sessions on new approaches for membrane protein structural biology and on lipid-protein interactions. The goal of the Gordon Research Conference on Ligand Recognition and Molecular Gating is to stimulate advances in this area of membrane protein research by bringing together some of the foremost scientists in this community to present and compare results, discuss new ideas, and establish collaborations.