PILOT/EXPLORATORY STUDIES CORE

试点/探索性研究核心(PESC)的目标是促进创新的多学科研究，重点是老年人残疾、康复和预防的潜在机制以及康复的功能和临床反应。PESC管理试点和探索性研究(PES)的推广、应用、审查、奖励和监测的过程。奖项的优先顺序 包括与伊斯兰会议组织主题的相关性、独立供资的潜力、新的多学科合作和翻译潜力。先期5年卓越的研究成果和学术成就证明了我们优良的环境、导师和学术成就。 支持PES的资源。OAIC自1994年成立以来，已颁发了58个试点奖助金。 2000-2005年伊斯兰会议组织出资46万美元资助的23个试点项目证明了PESC的成功，这些试点项目获得了超过280万美元的外部资金。在过去的5年里，PESC在16项试点研究中投资了371,000美元，迄今已出版了25份出版物，并获得了290万美元的外部资金。PESC资金 在进行PES的过程中，初级教员和其他人的指导对于改善患有慢性致残疾病的老年人的康复结果和康复至关重要，并与新的学术带头人一起推进基于运动的康复领域。 拟议的第一年试点研究包括：PES-1：通过分带跑步机训练改善中风幸存者的行走对称性和功能灵活性；PES-2：有氧运动可改善T2 DM患者的EPC和血管功能；PES-3：维生素D补充(D)加和不加多组分生活方式运动(Mlife)对D缺乏的老年人肌肉功能、炎症和葡萄糖代谢的影响；PES-4：阻力训练(RT)和蛋白质(Pro)补充以改善乳腺癌幸存者的肌肉生理学和减少疲劳；PES-5：中风后人类Gait动态皮质图谱的高密度脑电(EEG)神经解码研究。

The goal of the Pilot/Exploratory Studies Core (PESC) is to promote innovative multidisciplinary research focused on the mechanisms underlying disability, recovery and prevention in older persons and the functional and clinical responses to rehabilitation. The PESC manages the process of promotion, application, review, award and monitoring for Pilot and Exploratory Studies (PES). Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. The priori 5-year history of outstanding research productivity and academic accomplishments of pilot investigators attests to our excellent environment, mentors and academic resources in support of PES. This OAIC has made 58 pilot grant awards since its inception in 1994. Success of PESC is demonstrated by the 23 pilots funded in the 2000-2005 OAIC for $460,000 that have yielded over $2.8 million in extramural funding. During the last 5 years, PESC invested $371,000 in 16 pilot studies that have to date generated 25 publications and ~ $2.9 million in extramural funding. PESC funding and mentorship of junior faculty and others in the conduct of PES's is essential to improve the rehabilitation outcomes and recovery of older people with chronic disabling diseases and advance the field of exercisebased rehabilitation with new academic leaders. Proposed first year pilot studies include PES-1: Improving walking symmetry and functional mobility in stroke survivors with split-belt treadmill training; PES-2: Aerobic exercise to improve regulation of EPCs and vascular function in T2DM; PES-3: Effects of Vitamin D Repletion (D) with and without Multicomponent Lifestyle Exercise Training (MLife) on Muscle Function, Inflammation and Glucose Metabolism in D Deficient OlderAdults; PES-4: Resistance Training (RT) and Protein (Pro) Supplementation to Improve Muscle Physiology and Reduce Fatigue in Breast Cancer Survivors; PES-5: A High-Density Electroencephalography (EEG) Neural Decoding Study of Dynamical Cortical Mapping of Gait in Humans After Stroke.