课题基金 / 基金详情

Mouse coronary micro computed tomography

Mouse coronary micro computed tomography
小鼠冠状动脉显微计算机断层扫描
批准号：
8558076
负责人：
HAN WEN
金额：
$8.53万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8558076
关键词：
AnatomyApoE knockout mouseCoronaryCoronary ArteriosclerosisCoronary arteryDataDevelopmentGoalsHeartImageJournalsLesionMusOperative Surgical ProceduresPhasePreparationProtocols documentationPublicationsReportingSpecimenStructureSynchrotronsVariantWorkX-Ray Computed Tomographybasemouse model

项目摘要

项目成果

HAN WEN的其他基金

相关文献

中文摘要
翻译
在我们的研究之前，冠状动脉管型的MicroCT已经在转基因小鼠模型中显示出解剖学上的差异，但还没有开发出用于对冠状动脉疾病小鼠模型中的冠脉壁结构进行成像。我们已经开发了成像方案，并在apoE基因敲除小鼠中获得了数据，显示了完整心脏的冠脉壁和斑块成像。我们已经成功地用基于桌面和同步加速器的MicroCT对小鼠心脏标本的冠状动脉壁进行了成像。研究结果发表在《解剖学杂志》上。进一步的工作将集中在合适的小鼠模型和冠状动脉病变的手术准备方案上。
英文摘要
Prior to our study, microCT of coronary artery casts have shown anatomical variations in genetically modified mouse models, but has not been developed to image the coronary wall structures in mouse models of coronary artery disease. We have developed the imaging protocol and obtained data in apoE knockout mice that demonstrate coronary wall and plaque imaging in intact hearts. We have successfully imaged the coronary artery wall of mouse heart specimens with both tabletop and synchrotron based microCTs. The results are reported in a publication in Journal of Anatomy. Further work will focus on the appropriate mouse model and surgical preparation protocol for coronary artery lesions.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
New Non-invasive Imaging Methods For Biomedical Applicat
MRI of cardiac function and myocardial tissue properties
Advanced x-ray imaging and computed tomography
Compact x-ray nanoscopy