PACIFIC NW REGIONAL CENTER OF EXCELLENCE NHP CORE YELLOW FEVER

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 太平洋西北地区卓越中心（PNWRCE）非人灵长类核心是一个多中心的核心，旨在为美国国立卫生研究院国家过敏和传染病研究所（NIAID）感兴趣的传染病研究提供专用饲养动物和独特设施的资源和专业调查和技术知识，这些研究最好在非人灵长类动物中进行。 该核心的全球目标是提供必要的专门知识和专门基础设施，以开发和安全使用潜在生物威胁和新出现的危害公共健康的传染病的复杂非人类灵长类动物模型。该核心支持PNWRCE的非人灵长类传染病研究目标，以及来自俄勒冈州和华盛顿国家灵长类动物研究中心（ONPRC比弗顿，OR和WaNPRC，西雅图，WA）的性能站点的X区域内合作研究者的研究目标，以及位于落基山实验室（RML）校园（汉密尔顿，MT）的综合研究机构（IRF）。核心方案目前支助的研究活动包括使用黄热病病毒攻毒模型，在正常和高危受试者中深入测试黄热病病毒灭活疫苗原型的免疫原性、免疫持久性和效力;使用埃博拉病毒攻击模型用可复制的和有缺陷的疫苗载体进行免疫原性研究，确定有效埃博拉疫苗提供的保护的免疫相关性，并在易受感染的人群中测试疫苗的效力。（年轻和老年）受试者;开发用于测试预防基孔肯雅病毒感染的疫苗策略的攻击模型;以及使用猴痘攻击模型来测试旨在支持老年受试者中的病毒特异性CD 8 T细胞应答的策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Pacific Northwest Regional Center of Excellence (PNWRCE) Nonhuman Primate Core is a multicenter Core structured to provide resources for purpose-bred animals and unique facilities and specialized investigative and technical expertise for infectious disease research of interest to the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) that are best conducted in nonhuman primates. The global objective of the Core is to provide the necessary expertise and specialized infrastructure for development and safe use of complex nonhuman primate models of potential bio-threats and emerging infectious disease that endanger public health. The core supports the nonhuman primate infectious disease research objectives of the PNWRCE as well as those of collaborating investigators within Region X from performance sites at the Oregon and Washington National Primate Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Research activities currently supported by the core include use of a yellow fever virus challenge model for in-depth testing of the immunogenicity, durability of immunity and efficacy of a prototype killed yellow fever virus vaccine in normal and at-risk subjects; use of an Ebola virus challenge model to conduct immunogenicity studies with replication competent and defective vaccine vectors, determine immune correlates of protection conferred by an efficacious Ebola vaccine and test vaccine efficacy in vulnerable (young and old) subjects; development of a challenge model for testing vaccine strategies to prevent Chikungunya virus infection; and use of a monkey pox challenge model to test strategies aimed at bolstering virus-specific CD8 T cell responses in aged subjects.