CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource

CNS HIV抗逆转录病毒治疗效果研究（CHARTER）是响应RFA NIMH-00-AI-0005于2002年9月资助的，目的是探索在高活性抗逆转录病毒治疗（HAART）的背景下HIV神经系统并发症的变化。CHARTER的主要目的是确定不同的抗逆转录病毒治疗史和治疗方案如何影响艾滋病毒的中枢和周围神经系统并发症。在过去的8年里，6个地点的CHARTER项目积累了1598名参与者的宝贵临床和研究数据，其中674名参与者的纵向数据被收集。数据包括神经医学特征、神经心理功能、精神病学和药物滥用变量、治疗数据、脑成像以及病毒和宿主遗传信息。每次CHARTER访问产生大约4000个独立变量；目前，该数据库包含超过500万个数据点。

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in September 2002 in response to RFA NIMH-00-AI-0005 with the aim of exploring the changing presentation of HIV neurological complications in the context of highly active antiretroviral therapy (HAART). CHARTER's major aims were to determine how central and peripheral nervous system complications of HIV were being affected by different histories and regimens of ART. Over the past 8 years, the six-site CHARTER project has accumulated invaluable clinical and research data on 1598 participants, with longitudinal data being collected on 674 of these participants. Data includes neuromedical characterization, neuropsychological functioning, psychiatric and drug abuse variables, treatment data, brain imaging, and viral and host genetics information. Each CHARTER visit generates approximately 4000 individual variables; currently the database contains over 5 million datapoints. A key component of CHARTER is to serve as a catalyst for additional studies/analyses by making this wealth of data available to investigators. To date, the CHARTER Coordinating Core and CHARTER Resource have facilitated research requests for 70 investigators across 18 institutions. In order to continue to make samples and data available to the neuroAIDS community, we propose to extend the ¿CHARTER as a Resource¿ facilities beyond the original CHARTER Option Period.