Allergen and T-Cell Reagent Resources for the Study of Allergic Diseases

该合同支持两个不同的目标。第一个目标是支持核心设施，这些设施将使用创新的分离和纯化技术，从各种来源确定与人类疾病有关的新型过敏原，如哮喘、过敏性鼻炎和食物过敏。第二个目标是鉴定和表征含有T细胞表位的肽，所述T细胞表位诱导过敏原特异性效应T细胞中的无反应性，或激活过敏原特异性调节性T细胞。该计划的主要目标是使用创新的纯化方法鉴定新的过敏原，并产生一组定义的肽，调节过敏原特异性效应细胞和调节性T细胞的功能。这项研究可能会产生用于疫苗开发的新试剂。

This contract supports two distinct objectives. The first objective is to support core facilities that will use innovative isolation and purification techniques to identify novel allergens associated with human diseases, such as asthma, allergic rhinitis and food allergy, from various sources. The second objective is to identify and characterize peptides containing T cell epitopes that induce anergy in allergen-specific effector T cells, or activate allergen-specific regulatory T cells. The major goals of this initiative are to identify novel allergens using innovative purification methods, and to generate a set of defined peptides that regulate the function of allergen-specific effector and regulatory T cells. This research may lead to novel reagents for the use of vaccine development.