Biology, Biomechanics and Atherosclerosis

描述（由申请人提供）：本提案是为了继续支持我们的生物工程研究伙伴关系，题为生物学，生物力学和动脉粥样硬化。在我们BRP资助的前4年，我们的团队专注于更好地了解动脉粥样硬化的基本机制，特别关注生物力学力和动脉粥样硬化之间的相互关系。我们最初的努力范围广泛，结合了来自广泛的临床和学术领域的工程师，生物学家和临床医生的专业知识。在这方面，我们要求继续支持，我们选择将我们的努力集中在一个单一的动脉粥样硬化疾病实体，腹主动脉瘤（AAA）。我们采取这种方法是基于几个因素，包括临床问题的重要性，BRP成员开发的广泛的相关初步数据，以及BRP成员更加关注的潜在好处。 本BRP的总体目标是更好地了解AAA形成的生物学和生物力学，总体目标是获得对AAA发展潜在机制的新见解。这个项目是支持我的新的数据，从这个BRP的成员，牵连额外的蛋白质家族在适应不良的主动脉壁的重塑，发生在AAA的形成。该提案将侧重于在重塑的最早阶段发展动脉瘤，以便研究AAA形成的最生物学相关方面。

DESCRIPTION (provided by applicant): This proposal is for continued support of our Bioengineering Research Partnership entitled Biology, Biomechanics and Atherosclerosis. Over the first 4 years of our BRP funding, our group has focused on obtaining a better understanding of the basic mechanism of atherosclerosis with a particular focus on the interrelationships between biomechanical forces and atherosclerosis. Our initial efforts have been broad in scope incorporating the expertise of engineers, biologists and clinicians from an expansive range of clinical and academic areas. In this, our request for continued support, we have elected to focus our efforts on a single atherosclerotic disease entity, abdominal aortic aneurysms (AAA). We have taken this approach based on several factors including the importance of the clinical problem, the development of extensive, relevant preliminary data by members of the BRP and the potential benefit of having a greater focus for the members of the BRP. The overall goal of this BRP is to gain a better understanding of the biology and biomechanics of AAA formation with the overall goal of gaining new insights into the underlying mechanisms of AAA development. This project is support my novel data from the members of this BRP that implicate additional protein families in the maladaptive remodeling of the aortic wall that occurs during AAA formation. This proposal will focus on developing aneurysms at the earliest stages of remodeling so as to study the most biologically relevant aspects of AAA formation.