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Mouse coronary micro computed tomography

Mouse coronary micro computed tomography
小鼠冠状动脉显微计算机断层扫描
批准号：
8344932
负责人：
HAN WEN
金额：
$29.38万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8344932
关键词：
ApoE knockout mouseCoronaryCoronary ArteriosclerosisCoronary arteryDataDevelopmentGoalsHeartImageLaboratoriesManuscriptsMusPhaseProtocols documentationSourceStructureSynchrotronsVariantX-Ray Computed Tomographymouse model

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中文摘要
翻译
在我们的研究之前，冠状动脉铸型的microCT已经显示了转基因小鼠模型的解剖变异，但尚未开发用于冠状动脉疾病小鼠模型中的冠状动脉壁结构成像。我们已经开发了成像协议，并在apoE基因敲除小鼠中获得了数据，证明了完整心脏的冠状动脉壁和斑块成像。手稿正在准备提交，更多的数据获得的阿贡国家实验室同步加速器X射线源正在分析。
英文摘要
Prior to our study, microCT of coronary artery casts have shown anatomical variations in genetically modified mouse models, but has not been developed to image the coronary wall structures in mouse models of coronary artery disease. We have developed the imaging protocol and obtained data in apoE knockout mice that demonstrate coronary wall and plaque imaging in intact hearts. The manuscript is being prepared for submission, and more data acquired at the Argonne National Laboratory synchrotron x-ray source are being analyzed.
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