BISPHENOL A METABOLISM AND EFFECTS IN A PRIMATE MODEL

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 双酚A(BPA)是产量最大的化学品之一，在美国，超过90%的人每天接触到低水平的化学品。最近在老鼠身上的研究表明，暴露在低水平的这种雌激素化学物质中会对广泛的生物系统产生不利影响。然而，缺乏关于老鼠研究与人类接触的相关性的信息，这阻碍了利用这些研究为人类健康政策决策提供信息。来自灵长类动物模型的数据将有助于弥合老鼠和人类之间的差距。这项提案支持对国家卫生研究院已经资助的赠款的补充活动。资助的赠款“胎儿双酚A暴露对灵长类动物卵子发生的影响”涉及用双酚A治疗成年怀孕雌性恒河猴，以及评估对雌性胎儿卵子发生的影响。该项目包括两项额外的活动：1)研究BPA口服后的命运，以确定组织分布和排泄途径；2)资金，支持正在进行的NIH资助的研究中收集和分配灵长类组织给其他护照基金会资助的研究人员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bisphenol A (BPA) is one of the highest volume chemicals in production, and over 90% of people in the US are exposed to low levels on a daily basis. Recent studies in the mouse indicate that exposure to low levels of this estrogenic chemical adversely affects a wide range of biological systems. However, there is a lack of information about the relevance of mouse studies to human exposure, which has prevented the use of these studies to inform human health policy decisions. Data from a primate model will help to bridge the gap between mouse and human. This proposal supports supplemental activities to an already funded grant from NIH. The funded grant "Effects of Fetal Bisphenol A Exposure on Oogenesis in Primates" involves the treatment of adult, pregnant female rhesus monkeys with BPA and the assessment of effects on oogenesis in female fetuses. This project covers two additional activities: 1) a study of the fate of BPA once it is orally ingested to determine the tissue distribution and excretion pathways and, 2) funds to support the collection and distribution of primate tissues from an ongoing NIH funded study to other Passport Foundation-funded investigators.