DIET AND GENOTYPE IN PRIMATE ATHEROSCLEROSIS: VETERINARY SERVICES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这是计划项目“灵长类动脉粥样硬化的饮食和基因类型”的核心C。 核心单元C负责维护纯种狒狒群体，管理繁殖群体，并使用狒狒进行实验程序。群体维护包括日常护理，即喂食指定的饲料、清理笼子、观察动物是否有疾病迹象、治疗生病的动物以及维护动物数据库记录。繁殖群体的管理包括维护母坝分配、监测水坝是否怀孕、在动物数据库中记录出生情况，以及从群体中淘汰非繁殖力的动物。实验程序包括给予高胆固醇、高脂肪饮食挑战、采血、股动脉活检、肝脏活检、肌肉活检和脂肪组织活检。动物饲养员负责日常的动物养护工作。兽医或兽医技术员提供医疗保健，准备实验饮食，并负责实验程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is Core C of the Program Project "Diet and Genotype in Primate Atherosclerosis". Core Unit C is responsible for maintaining the pedigreed baboon colony, managing the breeding groups, and conducting the experimental procedures using baboons. Colony maintenance includes daily care, i.e., feeding assigned diets, cleaning cages, observing animals for signs of illness, treating sick animals, and maintaining animal database records. Breeding colony management includes maintaining sire-dam assignments, monitoring dams for pregnancies, recording births in the animal database, and culling unproductive animals from the colony. Experimental procedures include administration of the high cholesterol, high fat dietary challenge, blood collections, femoral artery biopsies, liver biopsies, muscle biopsies, and adipose tissue biopsies. Animal caretakers are responsible for animal maintenance on a daily basis. Veterinarians or veterinary technicians provide health care, prepare experimental diet, and are responsible for experimental procedures.