T1? MRI OF PATIENTS WITH ALZHEIMER?S DISEASE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 人们对早期诊断的新的非侵入性技术的发展非常感兴趣 阿尔茨海默病(AD)。对非侵入性测量不断增长的需求推动了 发展基于成像的方法。磁共振成像(MRI)是一种无创的 在神经系统疾病的设置中常规执行，实施新的基于MRI的 阿尔茨海默病的诊断和预后技术尤其有利。候补MR 对比度机制是旋转标架中的自旋晶格驰豫时间常数t1，它 生成与传统松弛时间(T1和T2)不同类型的对比度。 生物组织中的T1弛豫现象已被广泛研究并被证明是 对物理化学过程(如自旋-自旋相互作用、化学交换)敏感。在蛋白质中 和生物组织，不同环境中的质子之间的交换有助于T_1？ 放松一下。T1？MRI已被广泛应用于乳腺癌组织的定性、水平监测 软骨退化并勾勒出脑瘤。 本研究对AD、MCI和年龄匹配的对照组进行了脑内T1的测定。 并确定T1？在区分这三个队列中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is significant interest in the development of novel non-invasive techniques for the early diagnosis of Alzheimer disease (AD). The increasing demand for a noninvasive measurement has driven the development of imaging based methods. Magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD is especially advantageous. An alternate MR contrast mechanism is T1¿, the spin lattice relaxation time constant in the rotating frame, which generates a different type of contrast than that seen with conventional relaxation times (T1 and T2). T1¿ relaxation phenomena in biological tissues have been extensively studied and shown to be sensitive to physio-chemical processes (e.g. spin-spin interaction, chemical exchange). In proteins and biological tissues, exchange between protons in different environments contributes to T1¿ relaxation. T1¿ MRI has been widely used to characterize breast cancer tissue, monitor the level of cartilage degeneration and delineate brain tumors. The current study deal with the measurement of T1¿ in the brain of AD, MCI and age matched control, and determine the role of T1¿ in discrimination of these three cohorts.