MRI TECHNIQUES FOR SMALL ANIMAL NEURO-IMAGING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 最近建立了一种转基因小鼠模型(P301S，PS19系)来研究其特性 阿尔茨海默病(AD)的变态反应。神经病理的组织学特征显示 突触丢失、海马区小胶质细胞增多症、丝状tau包涵体和最终神经元的迹象 损失。这项研究的目标是利用磁共振无创地描述这些小鼠的特征 磁共振成像(MRI)，有可能将这些技术转化为早期临床环境 诊断阿尔茨海默病以及跟踪治疗反应。各种核磁共振技术可以是 适用于此任务，包括扩散张量磁共振成像(DTI)、高分辨率磁共振成像、动脉自旋标记 (ASL)灌注MRI、T1p MRI和化学交换饱和转移(CEST)成像。这 该项目目前正处于人员培训和初步扫描的早期阶段。体内 小型啮齿动物神经成像的方案将需要优化。由此产生的测量结果 并将图像与组织学和免疫组织化学特征进行比较。这是我们的 希望为小啮齿动物提供可广泛使用的磁共振成像技术以及该发现 AD的非侵入性生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A transgenic mouse model (P301S, PS19 line) was recently developed for studying the characteristic tauopathy of Alzheimer's Disease (AD). Histological characterization of the neuropathology shows signs of synapse loss, hippocampal microgliosis, filamentous tau inclusions, and eventual neuron loss. The goal of this study is to characterize these mice non-invasively using magnetic resonance imaging (MRI), with the potential to translate these techniques into the clinical setting for early diagnosis of AD, as well as for tracking treatment response. A variety of MRI techniques may be suited for this task, including diffusion tensor MRI (DTI), high resolution MRI, arterial spin labeling (ASL) perfusion MRI, T1p MRI, and chemical exchange saturation transfer (CEST) imaging. This project is currently at an early stage of personnel training and preliminary scanning. In-vivo protocols for small rodent neurological imaging will need to be optimized. Resulting measurements and images will be compared with histology and immunohistochemistry characterization. It is our hope to provide widely accessible MRI techniques for small rodent imaging, as well as the discovery of non-invasive biomarkers for AD.