STRUCTURAL STUDY OF BACTERIAL TOXINS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 细菌毒素引起各种病理效应。目前的研究建议调查少数已知细菌毒素的影响。主要目的是开发潜在的药物来治疗或预防与毒素有关的疾病。初步研究产生了一些潜在的目标和结构研究的目的是了解机制。出于安全考虑，我们将致力于基因改造的形式，这是灭活和无毒。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial toxins cause various pathological effects. The current study proposes to investigate the effect of few known bacterial toxins. The primary aim is to develop potential drugs to treat or prevent toxin related illness. The preliminary studies have generated few potential targets and the structural study is aimed at understanding the mechanism. Due to safety concern, we will be working on genetically modified forms which are inactivated and nontoxic.