HIGH RESOLUTION STRUCTURE OF BACTERIOPHAGE P22

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 噬菌体、疱疹病毒和其他大型dsDNA病毒含有分子机器。 将DNA泵入预先组装的前衣壳，引发与相关的成熟 颗粒大小变化、包装酶释放、蛋白质与细胞结合的级联作用 粒子的联合和激活以进行感染。这些事件与 衣壳的压力超过瓶装香槟的10倍，并通过 蛋白质开关，将信号从颗粒内部传递到颗粒外部。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacteriophages, herpesviruses and other large dsDNA viruses contain molecular machines that pump DNA into preassembled procapsids, triggering maturation with an associated cascade of particle size change, release of packaging enzymes, binding of proteins for cell association and activation of the particles for infection. These events are associated with capsid pressures exceeding, by 10-fold, that of bottled champagne, and are detected by a protein switch that transduces a signal from inside to outside of the particle.