THREE DIMENSIONAL VISUALIZATION IN VCELL

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 通过开发增强的可视化工具，Vcell的影响可以大大扩大，这些工具将大大减少开发Vcell BioModel所需的时间，并将模拟结果与实验结果进行比较。这些进展还将通过提供与生物过程数学模型交互的直观方法，促进更广泛类别的BASE和临床研究人员使用Vcell和其他空间模拟技术。为了增强Vcell建模环境，提出了两类可视化工具。AIM 1集成了增强的图形方法，用于创建Vcell生物模型并与其交互。我们集成了强大的图形方法，使用户能够高效地遍历反应网络环境，并在直观的界面中与系统交互，该界面允许在几何图形、反应路径、参数列表和最终模拟结果之间轻松移动。目标2开发复杂的三维可视化工具，用于显示和比较模拟结果和实验数据集。最终，开发的工具将被链接起来，以提供从原始BioModel到模拟结果的无缝集成，提供一个直观的界面，通过该界面，模型和模拟结果可以更容易地传播到建模社区之外。Vcell用户界面中增强的图形功能将有助于将这项技术的力量带入实验室和诊所，而这些实验室和诊所通常不具备利用先进建模技术的专业知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The impact of VCell could be significantly expanded by developing enhanced visualization tools that would vastly reduce the time required to developed a VCell BioModel and to compare simulation results to experimental results. These advances would also facilitate the use of VCell and other spatial simulation technologies by a broader class of both bench and clinical researchers by providing intuitive methods for interacting with mathematical models of biological processes. Two classes of visualization tools are proposed to enhance the VCell modeling environment. Aim 1 integrates enhanced graphical methods for creating and interacting with VCell BioModels. We are integrating powerful graphical methods to enable users to efficiently traverse the reaction network landscape and interact with the system in an intuitive interface that allows facile movement between geometry, reaction pathways, parameter lists, and ultimately simulation results. Aim 2 develops sophisticated three dimensional visualization tools for displaying and comparing simulation results and experimental data sets. Ultimately the tools developed will be linked to provide seamless integration from the original BioModel to the simulation results, providing an intuitive interface by which models and simulation results can be more easily disseminated beyond the modeling community. Enhanced graphics capabilities within the user interface of VCell will help to bring the power of this technology into laboratories and clinics that would not ordinarily have the expertise to utilize advanced modeling technologies.