IMAGING IN DEPTH IN TURBID MEDIA BY TWO-PHOTON FLUORESCENCE MICROSCOPY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 传统的双光子荧光显微镜技术仅允许在小于1 mm的深度处进行组织成像。该项目的目标是开发一种实用的设计，将能够在几毫米和更深的深度组织荧光成像。在该项目中使用的新提出的检测系统具有上级光收集效率和灵敏度，将允许在混浊介质的深层成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Conventional two-photon fluorescent microscopy technique allows tissue imaging only at depths less than 1mm. The project goal is to develope a practical devise that will be capable of fluorescent imaging in tissue at depths of few mm and deeper. The novel proposed detection system utilized in the project possesses superior light collection efficiency and sensitivity that will allow imaging in deep layers of turbid media.