Estrogen and Progestin Intervention in Brain Aging and Alzheimer's Disease

描述（由申请人提供）：我们正在计划并邀请所有受邀演讲者参加为期两天的“雌激素和黄体酮干预脑老化和阿尔茨海默病的机会之窗”会议。这次会议将在德克萨斯州沃斯堡北德克萨斯大学健康科学中心（UNTHSC）举行，将有许多目前参与全国机会之窗讨论的主要参与者参加。这次“机会之窗”会议的总体目标是提供关于妇女健康倡议记忆研究（WHIMS）的新科学和重新分析的权威更新，以确定数据是否支持或拒绝激素治疗在治疗/预防绝经后妇女认知能力下降方面的机会之窗假说。具体目标是：(1)组建一个关于“机会寡妇”主题的领先思想家团队，以考虑新科学并重新评估该主题的现有科学。(2)召集对激素治疗和阿尔茨海默病（AD）治疗、延迟和/或预防感兴趣的内分泌学家、老年病学家、妇科医生、神经科学家和其他人员。(3)创建一个以“机会之窗”为主题的自由交流思想的论坛，采用鼓励交流思想的新颖会议形式。(4)将会议纪要发表在高知名度的文本或期刊上。(5)评价会议在实现其既定目标方面的有效性。会议计划举办五场会议，其中包括一场研究生/博士后会议，年轻科学家将在会上展示他们未发表的数据，以解决机会之窗的问题。此外，数据闪电战会议将允许所有参与者就该主题提供“突发新闻”类型的数据。接下来将有三场会议，每一场会议都涉及机会之窗问题的不同方面。截至本次提交，所有提议的发言者都已确认愿意参加，会议领导人已确定，我们正在与会议记录提议文本的出版商进行最后谈判。除了这里所要求的30,000美元，我们已经在当地筹集了20,000美元来支持这次会议，并承诺筹集更多的资金来支持扩大研究生/博士后会议。最后，我们制定了一个评估计划，以评估会议的有效性和演讲者在实现会议目标方面的表现。由于到2020年绝经年龄妇女将达到4100万，因此发现适当的激素使用时间是非常必要和及时的。此外，尽管迫切需要重新考虑在一些绝经后妇女中使用激素来保护大脑，但我们并不知道在2012年安排了一个机会之窗会议。

DESCRIPTION (provided by applicant): We are planning and have commitments of all invited presenters for a two-day conference on the "Window of Opportunity for Estrogen and Progestin Intervention in Brain Aging and Alzheimer's disease". This meeting will be held in Fort Worth Texas at the University of North Texas Health Science Center (UNTHSC) and will feature many of the major participants currently engaged in the national discussion of the window of opportunity. The overall objective of this "Window of Opportunity" Conference is to provide an authoritative update on new science and reanalysis of the Women's Health Initiative Memory Study (WHIMS) to determine if data support or reject the hypothesis of a window of opportunity for hormone therapy in the treatment/prevention of cognitive decline in post-menopausal women. The specific objectives are: (1) To assemble a team of leading thinkers on the subject of "widow of opportunity" in order to consider new science and re-evaluate existing science on the subject. (2) To assemble an audience of endocrinologists, geriatricians, gynecologists, neuroscientists and others with an interest in hormone therapy and Alzheimer's disease (AD) treatment, delay and/or prevention. (3) To create a forum for free exchange of ideas on the subject of "window of opportunity", using a novel format for the meeting that encourages exchange of ideas. (4) To publish the proceeding of the meeting in a high profile text or journal. (5) To evaluate the effectiveness of the conference in achieving its stated objectives. Five sessions are proposed, including a graduate student/postdoctoral fellow session at which young scientists will present their unpublished data that address the issue of a window of opportunity. Also, a data blitz session will allow all participants to present "breaking news" type data on the topic. This will be followed by three sessions that each address different facets of the window of opportunity issue.! As of this submission, all proposed presenters have confirmed their willingness to participate, session leaders have been identified and we are in final negotiations with a publisher of the proposed text of the proceeding of the meeting. In addition to the $30,000 herein requested, we have raised $20,000 locally to support this conference and are committed to raising more funds to support expanding the graduate student/post-doctoral fellow session(s). Finally, we have in place an evaluation plan for the assessment of the effectiveness of the conference and the presenters in achieving the goals of the conference. This conference is needed and timely, since menopausal age women will reach 41 million by 2020 and discovering the appropriate timing of the right hormones is much needed. Also, we are not aware of a window of opportunity meeting scheduled in 2012, despite that urgent need for a reconsideration of the use of hormones for brain protection in some post-menopausal women. PUBLIC HEALTH RELEVANCE: Menopausal age women will reach 41 million by 2020 and discovering the appropriate timing of the right hormones is much needed. Also, we are not aware of a window of opportunity meeting scheduled in 2012, despite that urgent need for a reconsideration of the use of hormones for brain protection in some post- menopausal women. We propose a conference that invites many of the leading thinkers in the field to consider if timing of post-menopausal hormone therapy affects the response of the brain to these hormones.