Validating Particulate Matter Monitors for Multiple Parameters

描述（由申请人提供）：项目摘要/摘要这项拟议研究的总体目标是现场测试和验证最近开发的颗粒物监测器的多个参数，包括其可用性作为个人接触二手烟草烟雾（SHS）的工具。成人和儿童的各种症状和疾病都与SHS暴露有关，并且已经得出结论，SHS暴露没有安全水平，这是一种应激源和混淆因素。美国人口吸烟率的历史性下降与估计43%的美国人口目前暴露于显著水平的SHS，这表明了解SHS暴露模式，特别是贫困儿童仍然至关重要。标准的暴露工具都有问题;迫切需要客观、定量和能够评估个人暴露水平和途径的其他方法。 这项建议的重点是新的方法，用于评估个人暴露于SHS已内置到微型颗粒物监测器最近开发的小组领导的哥伦比亚大学和RTI。两个团队都专注于提供关键PM组件的实时数据，合规性和活动数据的方法，以及收集可以在实验室中通过非破坏性光学方法评估SHS的大小PM的过滤器。先前的工作已经表明，集成到RTI和哥伦比亚监测器中的活动监测器可以预测作为时间函数的通气率，允许估计潜在的吸入剂量作为一种额外的方法。我们的前提是，使用这两个新开发的空气监测器的优势将是，他们将提供评估的PM的复杂混合物，同时也提供了更强大的SHS曝光分布与曝光错误分类比传统的方法。 这项提议汇集了GEI化学传感器项目的两个小组和在纽约市和巴尔的摩进行内城哮喘队列研究的调查人员。这两个小组开发的微型微粒监测器的早期版本已成功地在实验室和实地测试中部署，今年仍在继续开发，重点是缩小尺寸和改进易用性，以降低实地成本和提高合规性。 有了这个团队，我们的目标将通过以下具体目标来实现：目标1）评估小型个人空气监测器在队列研究中的可用性和可接受性。目的2）评估暴露于二手烟和其他颗粒物来源的真实的时间和基于综合过滤器的方法的灵敏度和特异性。

DESCRIPTION (provided by applicant): Project Summary/Abstract The overall goal of this proposed study is to field test and validate recently developed particulate matter monitors for multiple parameters, including their usability as personal exposure tool for second hand tobacco smoke (SHS). A wide array of symptoms and diseases in both adults and children are associated with SHS exposure, and it has been concluded that there is no safe level of exposure to SHS, a stressor and confounder. The historical decline in smoking rates in the US population has leveled with an estimated 43% of the US population currently exposed to significant levels of SHS, suggesting that understanding the patterns of exposure for SHS, especially for poor children is still critically important. Standard exposure tools all have problems; additional methods, which are objective, quantitative and can assess personal exposure levels and pathways are critically needed. This proposal focuses on novel approaches for assessing personal exposure to SHS that have been built into the miniaturized particulate matter monitors recently developed by teams headed at Columbia University and RTI. Both teams have focused on approaches that provide both real-time data of key PM components, compliance and activity data, as well as collecting filters of sized PM that can be assessed in the lab for SHS by non-destructive optical methods. Prior work has shown that the activity monitors integrated into the RTI and Columbia monitors can predict ventilation rate as a function of time, allowing estimation of potential inhaled dose as an additional method. Our premise is that the advantages of using these two newly-developed air monitors will be that they will provide assessment of complex mixtures of PM while also providing more robust SHS exposure distributions with less exposure misclassification than traditional methods. This proposal brings together two groups from the GEI Chemical Sensor Program and investigators running inner city asthma cohort studies in NYC and Baltimore. Early versions of miniaturized particulate monitors developed by the two groups have been successfully deployed in lab and field tests and development is continuing in the current year, focusing on reductions in size and improvements in ease of use so as to decrease field costs and increase compliance. With this team, our goals will be accomplished via the following specific aims: Aim 1) Assess the usability and acceptability of the miniaturized personal air monitors for cohort studies. Aim 2) Assess the sensitivity and specificity of real time and integrative filter based methods for assessing exposure to second hand smoke and other sources of particulate matter.