Collaborations to Advance Research and Ethics (CURE)

描述（申请人提供）：西北生物医学研究协会（NWABR）是一个促进对生物医学研究的理解和支持的非营利组织，将利用其在生物伦理学教师培训和课程开发方面的丰富经验，以及其成员研究组织的伙伴关系，制定一个高度协作和多方面的外展计划，“理解科学和伦理的合作（CURE）。我们的长期目标包括增加公众对生物医学研究的性质以及科学与伦理学关系的理解，特别强调转化研究-将基础研究应用于临床疗法开发的过程。该项目的具体目标是：1）为初中和高中生命科学教育工作者提供教师专业发展和课程资源，以转化研究的科学和伦理为目标，2）为学生提供学习经验，增加他们对转化研究和伦理的理解，以及3）传播通过CURE计划开发的资源和材料。将包括下列活动：1）“生物医学研究-科学与伦理”教师专业发展研讨会，包括与研究机构的科学家和与审查研究方案的个人进行讨论的时间，2）为中学制定“研究诚信”课程，重点是研究过程和适用于科学行为的道德标准，在研究中使用动物，和人类临床试验，3）一个“生物医学研究员”计划，为高中三年级学生从代表性不足的少数民族背景，提供实验室访问，与科学家的互动，并广泛概述了研究过程，四、一个“青年道德峰会”，汇集了谁参加了我们的专业发展教师的学生参加与伦理学家和其他互动讨论学生和展示项目有关的生物伦理学。第二阶段的传播将通过与华盛顿大学合作开发在线教师课程、讲习班以及通过诸如美国生物科学研究所的生物科学网站等合作伙伴的网络来完成。课程评估将利用定性和定量的研究措施，包括实验组和控制组，以检查教师专业发展计划对学生学习的影响。 虽然一般公众享受生物医学研究的重要健康益处，但他们通常不知道产生新的治疗方法和疗法的过程，也不知道有助于确保负责任地进行研究的道德标准。例如，对于基础科学如何与药物和疗法的开发相关联，为什么需要动物，或者如何进行临床试验，存在相当大的误解。为了确保对研究事业的持续支持，有必要促进对生物医学研究过程的理解，并解决其伦理问题。

DESCRIPTION (provided by applicant): The Northwest Association for Biomedical Research (NWABR), a non-profit organization that advances the understanding and support of biomedical research, will utilize its extensive experience in bioethics teacher training and curriculum development as well as the partnership of its member research organizations to develop a highly collaborative and multi-faceted outreach program, "Collaborations to Understand Science and Ethics (CURE)". Our long-term goals include increasing public understanding of both the nature of biomedical research and the relationship of science and ethics, with a special emphasis on translational research - the process of applying basic research to the development of clinical therapies. The specific aims of this project are to: 1) Provide teacher professional development and curricular resources for middle and high school life science educators that target the science and ethics of translational research, 2) Provide learning experiences for students that will increase their understanding of translational research and ethics, and 3) Disseminate the resources and materials developed through the CURE program. The following activities will be included: 1) A 'Biomedical Research-Science and Ethics' teacher professional development workshop that includes time with scientists in research facilities and discussions with individuals who review research protocols, 2) Development of a 'Research Integrity' curriculum for secondary schools focused on the research process and ethical standards that apply to scientific conduct, the use of animals in research, and human clinical trials, 3) A 'Biomedical Research Fellows' program for high school juniors from underrepresented minority backgrounds that provides laboratory visits, interactions with scientists, and a broad overview of the research process, 4) A 'Youth Ethics Summit' that brings together students of teachers who have participated in our professional development to participate in interactive discussions with ethicists and other students and to showcase projects related to bioethics. Dissemination in Phase II will be accomplished by the development of an online teacher course in collaboration with the University of Washington, workshops, and through the web via partners such as the American Institute of Biological Science's ActionBioscience site. Program evaluation will utilize both qualitative and quantitative research measures, including experimental and control groups to examine the impacts of the teacher professional development program on student learning. While members of the general public enjoy the vital health benefits of biomedical research, they are generally unaware of the process that generates new treatments and cures, or the ethical standards that help ensure that research is responsibly conducted. For example, there is considerable misunderstanding about how basic science relates to the development of drugs and therapies, why animals are needed, or how clinical trials are conducted. To ensure continued support for the research enterprise, it is necessary to promote understanding of the process of biomedical research and also to address its ethical considerations.