Biostatistics Core

生物统计共享资源(BioSR)的主要目标是促进同行评议的研究 维克森林大学(CCCWFU)综合癌症中心成员。我们与 所有四个项目的成员(细胞生长和存活、临床研究、癌症预防和 控制、细胞损伤和防御)贯穿于癌症相关研究项目的所有阶段。主修 承担方法学、统计学和计算机相关问题的责任，包括研究 临床试验监测、中期审查和最终分析的设计、抽样、统计方面。 具体来说，BioSR支持以下五个方面：1)协议开发，即开发 适当的统计设计，编制统计章节，审查所有 提交CCCWFU审查的方案；2)方案监测，即监测病人应计费用和 在需要时进行中期分析；3)统计分析和出版物，即与 来自所有项目的CCCWFU调查人员提供数据统计分析和结果解释 协助出版调查结果；4)新赠款开发，即与CCCWFU调查人员会面，以 讨论潜在赠款的设计和分析计划，并进行定期赠款援助 计划与CCCWFU调查人员就潜在的赠款进行头脑风暴；以及5)领导力和 培训，即参加CCCWFU负责科学和行政决策的委员会 每月为CCCWFU成员举办研究方法专题系列研讨会。 对于CCCWFU来说，BioSR是一种利用率高、成本效益高的资源。2009年11月1日至10月 2010年31日，BioSR为癌症相关工作提供了超过5000小时的支持。在同一时间内 期间，BioSR协助了来自所有项目的115多名不同的研究人员(71名科学成员)和 CCCWFU内的卓越中心。此外，20项由调查员发起的机构议定书 开放，监测了30个由调查员发起的机构方案，(2010年)监测了20份手稿 在此期间，在生物科学研究中心的协助下，已出版并提交了30多份赠款。为即将到来的 授权期我们要求总计2.45 FTE的支持，分为统计、管理和 提供这些持续服务的编程支持。

The primary goal of the Biostatistics Shared Resource (BioSR) is to facilitate the peer-reviewed research of members of the Comprehensive Cancer Center at Wake Forest University (CCCWFU). We collaborate with members from all four programs (Cell Growth and Survival, Clinical Research, Cancer Prevention and Control, and Cellular Damage and Defense) throughout all phases of cancer-related research projects. Major responsibilities are assumed for methodological, statistical, and computer-related issues including study design, sampling, statistical aspects of clinical trial monitoring, interim reviews, and final analysis. Specifically, the BioSR supports the following five areas 1) Protocol Development, i.e., developing appropriate statistical designs, preparing statistical sections, and reviewing the statistical content of all protocols submitted for review at the CCCWFU; 2) Protocol Monitoring, i.e., monitoring patient accrual and performing interim analyses when needed; 3) Statistical Analyses and Publications, i.e., collaborating with CCCWFU investigators from all programs to provide statistical analyses of data and interpretations of results to assist in publications of findings; 4) New Grant Development, i.e., meeting with CCCWFU investigators to discuss the design and analysis plans for potential grants as well as conducting regular grant assistance planning sessions to brainstorm with CCCWFU investigators about potential grants; and 5) Leadership and Training, i.e., participating in CCCWFU committees responsible for scientific and administrative decisions and conducting a monthly seminar series in topics in research methods for CCCWFU members. The BioSR is a highly utilized and cost efficient resource for the CCCWFU. From Nov. 1, 2009 through Oct. 31, 2010, the BioSR provided over 5,000 hours of support for cancer related work. During the same time period, the BioSR assisted over 115 different investigators (71 Scientific members) from all Programs and Centers of Excellence within the CCCWFU. In addition, 20 investigator-initiated institutional protocols were opened, 30 investigator-initiated institutional protocols were monitored, 20 manuscripts (in 2010) were published and over 30 grants submitted with the assistance of the BioSR during this time. For the coming grant period we request at total of 2.45 FTEs of support divided into statistical, administrative and programming support to provide these continued services.