Molecular Medicine Training Program

描述(申请者提供)：凯斯西储大学医学院的分子医学培训项目是专门为培养博士后学生将科学进步带到床边而专门设计的。它利用四个因素来创造一个特别适合这一目的的环境。首先，该项目位于勒纳研究所，克利夫兰诊所和医学院的医生和科学家历来密切合作，将尖端研究集中在人类疾病的原因和治疗上。第二，在第一年期间设计了一个新的核心课程，以提供在人体器官系统和疾病方面提出的基本科学原理的坚实基础。研究报告和轮换、研讨会、期刊俱乐部和学生休养生会加强了基本科学原理在整个培训中的翻译应用。第三，培训计划包含了领导优秀翻译研究实验室的广泛培训人员，我们的学员在这些实验室进行轮换和论文工作。这些实验室的范围和实力，它们的协作互动，以及培训者对支持培训计划的承诺，都证明了培训计划中的大学科学环境。最后，为了确保每个受训者了解他们研究领域的临床方面，每个人都会选择一名临床导师来帮助组织个人的临床体验。通过这种经验，学员被介绍给病人的诊断和治疗的第一手基础。为了进一步强调与临床实践的联系，培训计划中的学生与勒纳医学院的医学生一起参加了一门联合课程。经验表明，这些正在受训成为内科科学家的医科学生，以及我们正在寻找基础科学观察的临床应用的受训人员，有许多值得相互学习的地方。这项提案寻求为培训计划内的7名学员提供资金。随着第四个班的录取，很明显，该培训计划已经获得了全国的认可，并吸引了越来越多的申请者，目前有27名符合培训补助金资格的学员与该计划有关。学员们正急切地准备成为NIH资助的下一代实验室的领导者，翻译基本的科学原理来满足患者的需求。这一计划是专门为满足最近NIH路线图中确定的翻译研究需求而设计的，这一事实解释了它的年轻，并强调了促进其成长和成熟的重要性。

DESCRIPTION (provided by applicant): The Molecular Medicine Training Program of the Case Western Reserve University School of Medicine is specifically designed to train pre-doctoral students to take scientific advances from "bench to bedside". It takes advantage of four factors to create an environment particularly suited to this purpose. First, this Program is located in the Lerner Research Institute where physicians and scientists from both the Cleveland Clinic and the School of Medicine have historically worked closely together to focus cutting edge research upon the causes and treatments of human illness. Second, a novel core curriculum has been designed throughout the first year to provide a solid foundation in basic scientific principles presented in the context of human organ systems and disease. Research presentations and rotations, seminars journal clubs, and a student retreat reinforce the translational application of the basic scientific principles throughout training. Third, the Training Program contains a broad range of trainers heading outstanding translational research laboratories in which our trainees perform rotations and thesis work. The range and strength of these laboratories, their collaborative interactions, and the commitment of the trainers to support of the Training Program is evidence of the collegial scientific environment within the Training Program. Finally, to ensure that each of the trainees comes to understand the clinical aspects of their area of investigation, each selects a Clinical Mentor who helps organize an individual clinical experience. Through this experience trainees are introduced to patient diagnosis and treatment on a first hand basis. To further emphasize the connection to clinical practice, students in the Training Program take a joint course with medical students of the Lerner College of Medicine. Experience has shown that these medical students who are in training to be physician scientists, and our trainees who are finding clinical application to basic scientific observations, have much to learn from one another. This proposal seeks funding for 7 trainees within the Training Program. With admission of its fourth class, it has become clear that the Training Program has gained national recognition and attracted an ever increasing number of applicants, with 27 training grant eligible trainees currently associated with the Program. The trainees are eagerly preparing to take their places as the leaders of the next generations of NIH funded laboratories translating basic scientific principles to address patient needs. The fact that this Program was specifically designed to address the needs for translational research identified in the recent NIH roadmap explains its youth, and emphasizes the importance of promoting its growth and maturation.