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Effect of oxygen homeostasis on cardiovascular and cancer biology

Effect of oxygen homeostasis on cardiovascular and cancer biology
氧稳态对心血管和癌症生物学的影响
批准号：
8746628
负责人：
PAUL M. HWANG
金额：
$59.97万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8746628
关键词：
AffectAtherosclerosisBioenergeticsBiologyCancer BiologyCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemDNA DamageDevelopmentEnergy MetabolismGenomicsHealthHomeostasisLong-Term EffectsOxygencancer preventioninterestmitochondrial dysfunctiontumorigenesis

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中文摘要
翻译
我们之前的研究表明，线粒体功能障碍导致氧化性基因组DNA损伤，并有助于肿瘤的发生。然而，氧气也是细胞生物能量学的重要因素。我们目前正在进行调节氧稳态的研究，以检验其对能量代谢和肿瘤发生的影响。氧也深刻地影响心血管功能和疾病，因此我们有兴趣研究氧稳态可能影响动脉粥样硬化的机制。
英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. However, oxygen also serves as an essential factor for cellular bioenergetics. We are currently pursuing studies to modulate oxygen homeostasis to examine its effect on energy metabolism and tumorigenesis. Oxygen also profoundly affects cardiovascular function and diseases, so we are interested in examining the mechanisms by which oxygen homeostasis may affect atherosclerosis.
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