Center for the Study of Reproductive Biology and Women's Health

描述(由申请人提供)：拟议的生殖和不孕不育研究专业合作中心计划(SCCPIR)专注于女性生殖生物学，杰弗里·W·波拉德博士担任首席研究员。它由一个机构支持的“生殖生物学和妇女健康研究中心”演变而来，该中心于2003年在阿尔伯特·爱因斯坦医学院成立，波拉德博士担任主任。该中心汇集了该机构在女性生殖方面的不同研究线索，形成了一个以翻译为重点的不同的互动个体小组。该中心的研究人员在过去四年里一直致力于编写这份意见书，并在此过程中定期举行会议，开展合作项目，并利用机构资金支持与女性生殖研究相关的临床研究金培训。在这样做的过程中，提议的项目的PI都已经相互发表，他们已经确定了几名研究员将被带到教职员工进行临床/基础科学研究。 SCCPIR有四个项目(项目1和2为临床项目)和一个行政核心如下： 项目1.杰弗里·波拉德博士(PI)--雌激素和孕激素对人类子宫内膜细胞增殖的调控。 项目2.纳内特·桑托罗博士(PI)--肥胖中的生殖荷尔蒙变化。 项目3：Anne Etgen(Pi)-IGF-I博士与女性生殖功能的神经内分泌调节。 项目4.Streamson Chua博士(PI)-黑素皮质素和瘦素对生殖能力的拮抗作用。 所有这些项目都由一名高级调查员领导。通过研究肥胖和营养在生殖生物学中的作用以及胰岛素样生长因子-1轴和雌激素作用之间的关系，这些项目之间进行了整合。国际和平研究所杰弗里·W·波拉德博士是一位国际知名的生殖生物学研究人员，曾担任生殖道戈登会议主席等。他在医学院担任多个高级行政职位，并能在内部管理拟议的委员会，并与其他委员会进行有效的互动。

DESCRIPTION (provided by applicant): The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported "Center for the Study of Reproductive Biology and Women's Health" founded in 2003 at the Albert Einstein College of Medicine with Dr. Pollard as Director. This Center drew together disparate strands of research in the female reproduction at the institution to form a distinct group of interactive individuals who have a translational focus. Investigators with this Center have worked for the last four years to develop this submission and in doing so have met regularly to undertake collaborative projects and used institutional funds to support clinical fellowship training relevant to the study of female reproduction. In doing so the PI's of the proposed projects have all published with one another and they have identified several fellows to be brought onto faculty to perform clinical/basic science research. The SCCPIR has four Projects (Projects 1 and 2 being clinical) and an administrative core as follows: Project 1. Dr. Jeffrey Pollard (PI) - Estrogen and Progesterone Regulation of Human Endometrial Cell Proliferation. Project 2. Dr. Nanette Santoro (PI) - Reproductive hormonal alterations in obesity. Project 3. Dr. Anne Etgen (PI) - IGF-I and Neuroendocrine Regulation of Female Reproductive Function. Project 4. Dr. Streamson Chua (PI) - Antagonistic actions of melanocortins and leptin on reproductive competence. A senior investigator leads all of these projects. There is integration amongst the projects through studies on the roles of obesity and nutrition in reproductive biology as well as the relationship between the insulin-like growth factor-1 axis and estrogen action. The PI, Dr. Jeffrey W. Pollard, is an internationally known researcher in reproductive biology having been, amongst other things, Chair of the Reproductive Tract Gordon Conference. He holds several senior administrative appointments in the College of Medicine and is well able to administer the proposed SCCPIR internally and to enable effective interactions with other SCCPIRs.