Autoimmunity and Immunopathology Training Program

描述(由申请者提供)：这是匹兹堡大学医学院在自身免疫和免疫病理学方面的新培训计划。我们相信，自身免疫和免疫病理学的研究为年轻科学家提供了具有挑战性和激动人心的机会。适当的培训需要深入接触免疫学的当代概念和免疫病理学的临床方面。这一拟议的自身免疫学和免疫病理学培训计划的目标是培养具有进行跨学科、前沿研究能力的优秀学员(四名博士后和三名博士后)。我们将在匹兹堡大学翻译研究的现有优势基础上再接再厉。此外，匹兹堡大学在自身免疫研究领域拥有专业知识的新成员意味着，现在有足够多的研究人员来提供这一亟需的培训计划。我们的几名教员正在从事临床前研究，然后在临床上进行测试。我们将通过将从事自身免疫和免疫病理学(免疫学、细胞生物学、分子遗传学和临床风湿学)相关研究的教职员工和受训人员聚集在一起来实现这一目标。拟议的方案是在一个大型项目的框架内。位于匹兹堡大学医学院的跨学科生物医学研究生计划(IBGP)，鼓励几个学科之间的互动，使学员能够掌握当代生物学的不同领域。拟议的计划还利用了已建立的免疫学(IMM)研究生计划和匹兹堡大学几个临床系的额外教员，包括关节炎研究所。IMM研究生课程由医学院几个系的教员组成，与关节炎研究所提供的专门培训一起，提供全面的正式入门和专门课程，将提供自身免疫和免疫病理学的统一培训。这一拟议的培训计划得到了匹兹堡大学教员的支持和支持，这些教员在自身免疫、免疫病理学和相关研究领域拥有良好的培训记录，最近扩大了设施，并获得了强大的机构支持。 相关性(见说明)：自身免疫和免疫病理疾病的发病率不断增加，加上许多此类疾病缺乏有效的治疗方法，这突出表明需要招募年轻科学家来选择研究这些疾病的职业。该计划还将解决全国进入风湿病和相关学科领域的内科科学家短缺的问题。

DESCRIPTION (provided by applicant): This is a new training program in Autoimmunity and Immunopathology at the University of Pittsburgh School of Medicine. We believe that research in autoimmunity and immunopathology provides challenging and exciting opportunities for young scientists. Adequate training requires intense exposure to contemporary concepts in immunology and clinical aspects of immunopathology. The goal of this proposed training program in autoimmunity and immunopathology is to produce outstanding trainees (four predoctoral and three postdoctoral) with the ability to perform interdisciplinary, cutting-edge research. We will build on the existing strengths in translational research here at the University of Pittsburgh. In addition, new recruits to the University of Pittsburgh with expertise in the area of autoimmunity research mean that there is now a critical mass of investigators to provide this much needed training program. Several of our faculty are engaged in preclinical studies which are then tested in the clinic. We will achieve this by bringing together faculty and trainees performing research related to autoimmunity and immunopathology (immunology, cell biology, molecular genetics and clinical rheumatology). The proposed program is within the framework of a large. Interdisciplinary Biomedical Graduate Program (IBGP) based in the University of Pittsburgh, School of Medicine that encourages interactions among several disciplines and that enables trainees to master different fields of contemporary biology. The proposed program also draws from the established Immunology (IMM) Graduate Program and additional faculty in several University of Pittsburgh clinical departments, including the Arthritis Institute. The IMM graduate programs consist of faculty from several departments in the School of Medicine, and together with the specialized training provided by the Arthritis Institute, offer a comprehensive range of formal introductory and specialized courses that will afford unified training in autoimmunity and immunopathology. This proposed training program is enabled and supported by faculty with strong records as trainers in autoimmunity, immunopathology and related areas of research, recently- expanded facilities, and strong Institutional support at the University of Pittsburgh. RELEVANCE (See instructions): The increasing incidence of autoimmune and immunopathological conditions coupled with a lack of effective therapies for many of these diseases highlights the need to recruit young scientists to choose a career in investigating these diseases. This program will also address the national shortage of physician-scientists entering the field of rheumatology and related disciplines.