Enhancing Participation of Underrepresented Groups in Biomarker Studies

该项目将需要与威斯康星州部落和族裔/种族少数群体的代表合作进行一项研究，旨在确定和加强对生物标记物研究的参与。生物标志物研究依赖于收集体液，如血液或脑脊液、组织、功能或结构成像。特别重要的是让部落、移民和少数群体参与这些研究，因为这些群体背负着不成比例的慢性病和残疾负担。未能让这些群体参与生物标记物研究实际上是因为未能识别出 风险差异的原因以及环境、社会经济和行为变量对健康结果的中介/调节作用。我们将使用基于社区的参与性研究(CBPR)方法来确定和解决生物标记物研究参与的障碍。使用基于卫生服务利用框架的混合方法，社区-学术研究团队将检查参与阿尔茨海默氏症、肺部和心血管疾病以及癌症的生物标记物研究项目的障碍和促进者。这一框架基于计划行为/理性行动理论(TPB)和安徒生的健康行为模式(HBM)，已被用于评估参与癌症临床试验的意愿。它侧重于影响行为意图(参与决定)的认知因素。这些团队的发现将有助于为文化定制教育材料的开发提供信息，这些材料将进行试点，以检查是否/如何能够衡量参与生物标记物研究的意图。我们的整个活动旨在让少数群体和医疗服务不足的个人更多地参与到生物标志物研究中来。

This project will entail partnering with representatives of Wisconsin tribal and ethnic/racial minority groups in a study designed to identify and enhance participation in biomarker research. Biomarkers research relies upon the collection of bodily fluids such as blood or cerebrospinal fluid, tissue, functional or structural imaging. It is particularly important to engage tribal, immigrant and minority populations in these studies since these groups bear a disproportionate burden of chronic disease and disability. The failure to engage such groups in biomarker research actually serves to increase health disparity 'gaps' by failing to identify the causes of risk differences and mediating/moderating effects of environmental, socioeconomic and behavioral variables on health outcomes. We will use a community based participatory research (CBPR) approach to identify and address the barriers to biomarker study participation. Using a mixed methods approach based on a health services utilization framework, community-academic research teams will examine barriers and facilitators to participation in biomarker research projects for Alzheimer's, pulmonary and cardiovascular disease and cancer. This framework, based on the Theory of Planned Behavior/Reasoned Action (TPB) and Andersen's health behavior mode (HBM), has been used to examine willingness to participate in cancer clinical trials. It focuses on the cognitive factors that effect behavioral intentions (the decision to participate). The findings of these teams will serve to inform the development of culturally tailored educational materials that will be piloted to examine whether/how intent to participate in biomarker research can be measured. Our activities in whole are designed to bring visibility to and increase participation of minority and medically underserved individuals in biomarker studies.