Harvard Transdisciplinary Research in Energetics and Cancer Center

为了响应国家癌症研究所重新发布的能量学与癌症跨学科研究（TREC）倡议，（RFA-CA-10-006），我们建议建立一个TREC中心，利用哈佛大学哈佛公共卫生学院（HSPH）、哈佛医学院和哈佛附属布里格姆妇女医院、波士顿儿童医院、丹娜-法伯/哈佛癌症中心、哈佛朝圣者医疗保健研究所和哈佛人口与发展研究中心。我们已发展了四个相辅相成和相互关联的研究项目，由四个核心和参与机构的额外现有资源支持。他们共同组成了一个有凝聚力的跨学科中心，专注于新知识的产生及其翻译，培训和职业发展。在项目1中，我们将检查项目Viva中儿童的睡眠时间、能量平衡和胰岛素抵抗;在项目2中，我们将检查能量因素之间的关系（包括饮食胰岛素需求，客观测量的能量消耗和体力活动），睡眠时间和建筑环境与新的癌症生物标志物（胰岛素-IGF轴、脂肪因子和性激素）;在项目3中，我们将研究能量因素之间的关系（膳食胰岛素需求，肥胖，和体力活动）和胰岛素/IGF途径的生物标志物与前列腺癌生存率的关系;在项目4中，我们将进行一项随机试验，以评估基于理论的运动干预（单独或与药物干预相结合）是否会降低之前与结直肠癌幸存者预后不良相关的胰岛素和其他生物标志物的循环水平。这些项目将由四个核心支持：行政，教育/培训，生物信息学和发展。通过这些高度整合的项目和支持核心，我们的目标是培养博士后研究员和初级教师在跨学科的环境中追求职业生涯在能量学和癌症，并促进创新的跨学科研究项目，建立在中心和整体TREC计划的愿景和资源。正如哈佛公共卫生学院院长Julio Frenk博士和DF/HCC主任兼Dana-Farber癌症研究所所长Edward Benz博士的信中所述，我们已经获得了强有力的机构承诺。通过利用TREC中心内部和之间的多个专业领域和不同资源，我们可以帮助进一步建立一个独特的能量学和癌症知识的国家资源。

In response to the National Cancer Institute re-issue of the Transdisciplinary Research on Energetics and Cancer (TREC) initiative (RFA-CA-10-006), we propose to establish a TREC Center that draws on the multidisciplinary expertise of the faculty of Harvard University at the Harvard School of Public Health (HSPH), Harvard Medical School and the Harvard-affiliated Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber/Harvard Cancer Center, Harvard Pilgrim Health Care Institute, and the Harvard Center for Population and Development Studies. We have developed four complementary and interrelated research projects which are supported by four cores and additional existing resources at the participating institutions. Together, they form a cohesive, transdisciplinary center focused on the generation of new knowledge and its translation, training, and career development. In Project 1, we will examine sleep duration, energy balance, and insulin resistance among children in Project Viva; in Project 2, we will examine the relation of energetic factors (including dietary insulin demand, objectively measured energy expenditure, and physical activity), sleep duration, and the built environment with novel cancer biomarkers (insulin-IGF axis, adipokines, and sex hormones) in the Nurses' Health Study; in Project 3, we will examine the relation of energetic factors (dietary insulin demand, adiposity, and physical activity) and biomarkers of the insulin/IGF pathway with prostate cancer survivorship in the Physicians' Health Study; and in Project 4, we will conduct a randomized trial to evaluate whether a theory-based exercise intervention, alone or in combination with a pharmacological intervention, decreases circulating levels of insulin and other biomarkers previously linked to poor prognosis among colorectal cancer survivors. These projects will be supported by four cores: Administrative, Education/Training, Bioinformatics, and Developmental. Through these highly integrated projects and supporting Cores, we aim to train postdoctoral fellows and junior faculty in a transdisciplinary environment to pursue careers in energetics and cancer and to foster innovative transdisciplinary research projects that build on the Center's and the overall TREC program's vision and resources. We have obtained strong institutional commitment, as outlined in the letters from Dr. Julio Frenk, Dean of the Faculty, Harvard School of Public Health, and Dr. Edward Benz, Director of the DF/HCC and President of the Dana-Farber Cancer Institute. By leveraging multiple areas of expertise and different resources within and across TREC centers, we can help further build a unique national resource of energetics and cancer knowledge.