BIOSTATISTICS

芝加哥大学综合癌症中心(UCCCC)的生物统计核心设施(BCF)为从事临床、基础和人口科学研究的UCCCC研究人员提供协作性统计支持。除科学和技术主任外，该基金目前的工作人员包括5名博士统计员、2名硕士级生物统计师和1名研究计划员。BCF提供的服务包括协作形成研究设计和数据分析计划；1期、11期和111期临床试验的方案制定、随机化和统计分析；协助设计和分析回顾性和前瞻性观察性研究；以及基础科学和动物研究项目的统计合作。澄清要检验的具体目标和假设、说明主要和次要结果变量、计算样本量(力量)和制定数据分析计划是研究设计阶段的主要活动领域，随后是统计分析和协助编写手稿，以便在数据收集完成后出版。BCF还与癌症临床试验办公室和UCCCC IT小组就数据库开发和数据管理程序进行密切互动，以确保在UCCCC内进行的临床试验和其他研究的高水平数据质量，以及新开发的生物信息学核心，以支持从事生物信息学研究和其他研究的研究人员

The Biostatistics Core Facility (BCF) of the University of Chicago Comprehensive Cancer Center (UCCCC) provides collaborative statistical support to UCCCC investigators engaged in clinical, basic, and population science research. The Facility is currently staffed by five PhD statisticians, two masters level biostatisticians, and one research programmer in addition to the Scientific and Technical Directors. The services provided by the BCF include collaboration in the formation of study designs and data analysis plans; protocol development, randomization, and statistical analysis for Phase 1, Phase 11, and Phase 111 clinical trials; assistance in the design and analysis of retrospective and prospective observational studies; and statistical collaboration on basic science and animal research projects. Clarification of specific aims and hypotheses to be tested, specification of primary and secondary outcome variables, sample-size (power) calculations, and development of data analysis plans are major areas of activity during the study design phase, followed by statistical analysis and assistance in the preparation of manuscripts for publication after completion of data collection. The BCF also interacts closely with the Cancer Clinical Trials Office and the UCCCC IT group on database development and data management procedures to ensure a high level of data quality for clinical trials and other studies conducted within the UCCCC, as well as the newly developing Bioinformatics Core to support investigators engaged in bioinformatics research and other