Multidisciplinary Training in Brain Disorders and Development

描述（由申请人提供）：这个博士后培训计划的目标是培养年轻的科学家，并促进职业生涯专注于理解和开发发育性脑疾病的治疗。计划在与神经发育障碍研究有关的科学学科中进行多学科培训。因此，从4个系选出了23名培训教员。其中包括：3名医学博士，7名医学博士/博士和13名博士。现有教授12人，副教授5人，助理教授6人。目前有95名博士后学生在学院的实验室培训，包括7名MD/PhD，11名MD和77名博士。约翰·斯旺博士将继续担任项目主任，负责项目的日常运作。Huda Zoghbi博士和Jeff Noebels博士将继续担任联合主任。培训的主要领域包括神经发育障碍的遗传和分子基础，包括但不限于：Rett综合征，Angelman综合征，脆性X综合征和自闭症。培训的另一个集中领域是癫痫，其中遗传性和获得性癫痫的分子基础被研究。所有实验室都采用尖端的生物技术来创建和研究相关的疾病动物模型，不仅为了了解这些疾病的生物学基础，而且为了筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在过去几年的支持，24博士后学生迄今已进入我们的培训计划，8已接受在主要大学的教师职位。其中包括4名MD/PhD儿童神经学家，他们已获得K 08赠款，目前正在从事研究工作。提供了三条培训路线。一个是MD/PhD和具有丰富研究经验的MD。另一个是经验较少的医学博士，那里的培训更正式，包括实验室轮换和研究生课程。博士通过晚餐讨论、临床会议和专科诊所接受神经发育障碍临床方面的大量培训。简和丹邓肯神经研究所（NRI）的开幕是得克萨斯州儿童医院和贝勒医学院致力于发育障碍神经生物学研究的最新和戏剧性的证明。这个培训项目现在设在NRI，NRI有望成为大脑发育异常研究和培训的主要中心。通过培养优秀的研究科学家，我们认为对婴幼儿毁灭性神经系统疾病的新理解和治疗方法将会出现。

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists and promote careers focused on understanding and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 23 training faculty have been selected from 4 departments. They include: 3 MDs, 7 MD/PhDs and 13 PhDs. There are: 12 Professors, 5 Associate Professors and 6 Assistant Professors. There are currently 95 postdoctoral students training in laboratories of the faculty and include 7 MD/PhDs, 11 MDs and 77 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All labs employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. Over the past years of support, 24 postdoctoral students have thus far entered our training program and 8 have accepted faculty positions at major universities. These include 4 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through dinner discussions, clinical conferences and subspecialty clinics. The opening of the Jan and Dan Duncan Neurological Research Institute (The NRI) is the most recent and dramatic demonstration of the commitment of Texas Children's Hospital and Baylor College of Medicine to the study of the neurobiology of developmental disorders. This training program is now based in the NRI, which promises to become a major center for the study of and training in developmental brain abnormalities. By training outstanding research scientists, we feel new understandings and treatments for the devastating neurological disorders of infants and young children will emerge.