Infectious Diseases Training Program

描述（由申请人提供）：传染病仍然是对人类健康最重要的全球威胁；然而，正在接受培训、准备从事学术研究的医师科学家数量不足，这些学术研究可能会影响我们对传染病发病机制和治疗的理解。我们建议继续UT西南大学（UTSW）传染病博士后培养计划，培养医师科学家进行与宿主-病原体相互作用相关的前沿基础科学研究。该项目为成人和儿童传染病研究员（以及对宿主-病原体相互作用感兴趣的肺部、消化和肝脏研究员）提供培训。该计划的总体目标是培养在传染病相关学术研究领域取得成功的内科科学家。研究培训的具体目标是使受训者：(1)熟练掌握宿主-病原体相互作用领域中与传染病研究有关的最新技术；(2)获得生物医学科学相关领域的专业知识，如微生物遗传学、免疫学、细胞生物学、生物化学或药理学；(3)在提出强有力的研究假设和严格的实验设计和数据解释方面获得专业知识和独立性；(4)完成一项指导的研究项目，并发表一篇或多篇同行评议的第一作者出版物和NIH职业发展奖申请。这些目标将通过以下方式来实现：(1)在我们的22名项目培训教师（他们都是美国国立卫生研究院资助的杰出科学家，在宿主-病原体相互作用领域进行令人兴奋的工作）的实验室中进行强化监督的基础科学研究经验；(2)全面的教学课程，包括生物医学、伦理学、统计学和职业发展方面的必修课和选修课；(3)主要导师和论文委员会成员的积极指导和职业发展；(4)在一个高度互动和刺激的跨学科科学环境中进行训练的机会。这种全面和多方面的方法将培养传染病研究博士后，这些博士后有很强的潜力在学术研究事业上取得成功，并有很强的潜力进行基础科学研究，这将影响传染病的预防和/或治疗。

DESCRIPTION (provided by applicant): Infectious diseases continue to represent the most important global health threat to mankind; yet inadequate numbers of physician-scientists are being trained who are prepared for academic research careers that can impact our understanding of the pathogenesis and treatment of infectious diseases. We propose the continuation of the UT Southwestern (UTSW) Infectious Diseases postdoctoral training program to train physician-scientists to perform cutting edge basic science research related to host-pathogen interactions. This program provides training for Adult and Pediatric Infectious Diseases Fellows (as well as Pulmonary and Digestive and Liver Fellows who are interested in host-pathogen interactions). The overall goal of this program is to train physician-scientists for successful careers in academic infectious diseases-related research. Specific goals of the research training are for trainees to: (1) develop proficiency in state-of-the art- techniques relevant to infectious diseases research in the area of host-pathogen interactions; (2) gain expertise in a relevant area of biomedical science, such a microbial genetics, immunology, cell biology, biochemistry, or pharmacology; (3) gain expertise and independence in generating strong research hypotheses and in rigorous experimental design and data interpretation; and (4) complete a mentored research project that leads to one or more first-authored peer reviewed publications and NIH career development award applications. These goals will be accomplished by a combination of (1) intensive supervised basic science research experience in the laboratories of our 22 program training faculty (all of whom are outstanding NIH-funded scientists performing exciting work in the field of host-pathogen interactions); (2) a comprehensive didactic curriculum that includes required courses and electives in biomedical sciences, ethics, statistics, and career development; (3) active mentoring and career development by the primary mentor and thesis committee members; and (4) the opportunity to train in a highly interactive and stimulating interdisciplinary scientific environment. This comprehensive and multi-faceted approach will result in the training of post-doctoral fellows in Infectious Diseases research with strong potential to succeed in academic research careers and strong potential to perform basic science research that will impact the prevention and/or treatment of infectious diseases. PUBLIC HEALTH RELEVANCE: The goal of the UT Southwestern Infectious Diseases Training Program is to provide Adult and Pediatric Infectious Diseases Fellows (and other clinical fellows with a research interest in Infectious Diseases) with in-depth research training i the area of the biology of pathogens and host-pathogen interactions. This training will prepare them for careers as physician scientists in academic medicine and enable them to discover new knowledge that will advance our understanding of the causes and treatment of infectious diseases. To achieve this goal, the program provides an intensive 2-3 year experience in basic science research supplemented by formal didactic instruction in biomedical sciences, career development, and ethics.