2012 CSHL Nuclear Receptors & Disease Conference

项目概述本提案为将于2012年10月30日至11月3日在冷泉港实验室举行的“核受体与疾病”会议寻求支持。会议将聚集该领域的领导者，以及初级教师，博士后研究员和研究生，讨论我们对核受体的生理和细胞功能及其在人类疾病中的作用的理解的最新进展。核受体是与DNA结合并调节基因表达的蛋白质，以响应与受体结合的小“信使”分子。通过这种信使受体系统，有关环境和细胞代谢状况的重要信息被传递给基因组，从而导致基因表达的变化。这些受体在细胞生长、分化和代谢中起着非常重要的调节作用，这些受体的失调可导致代谢性疾病和不同类型的癌症。会议将涵盖广泛的主题，从详细的分子作用机制到组织水平的临床意义。每次会议将由该领域的一位顶尖科学家主持。口头报告将由一组杰出的受邀演讲者以及从提交的摘要中选出的演讲者进行。选定的演讲者将包括研究生，博士后研究员和初级教师，旨在最大限度地包括年轻研究人员。特别重要的是两次海报会议，许多参与者可以在有利于非正式讨论的气氛中介绍他们的工作。会议规模适中，预计约有250人参加，其中绝大多数人将展示海报或演讲。

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Nuclear Receptors and Disease October 30 - November 3, 2012 Project Summary This proposal seeks support for the meeting on "Nuclear Receptors and Disease" to be held at Cold Spring Harbor Laboratory October 30 - November 3, 2012. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of the physiological and cellular function of nuclear receptors as well as their role in human diseases. Nuclear receptors are proteins that bind to DNA and regulate gene expression in response to small "messenger" molecules that bind to the receptors. By means of this messenger-receptor system important information about the environment and the metabolic condition of the cell is communicated to the genome thereby leading to changes in gene expression. These receptors play very important roles as regulators of cellular growth, differentiation and metabolism, and dysregulation of these receptors can lead to metabolic diseases and different types of cancer. The meeting will cover a broad spectrum of topics ranging from detailed molecular mechanism of action to clinical implications at the organismal level. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. PUBLIC HEALTH RELEVANCE: Nuclear Receptors and Disease PROJECT NARRATIVE Nuclear receptors are important proteins in our cells which bind to small chemical messengers and interpret these individual signals by binding to DNA and regulating the expression of genetic information in specific ways. These proteins control the growth, metabolism and fate of cells, and malfunction or dysregulation of these receptors can lead to metabolic diseases (e.g. obesity, diabetes and cardiovascular diseases) and to different types of cancer (e.g. breast and prostate cancer). Understanding the basic activity of nuclear receptors and how these may become disrupted is of great importance for our ability to understand and treat these diseases. To provide a venue for interaction between basic and clinical researchers working on different aspects of nuclear receptors, we propose to hold a meeting entitled Nuclear Receptors and Disease at Cold Spring Harbor Laboratory in November 2012.