Neurobehavioral Assessment of Interpersonal Functioning in PTSD

描述(由申请人提供)： 摘要愤怒和攻击性是创伤后应激障碍(PTSD)治疗中严重且常见的并发症。大量研究表明，人际攻击和愤怒与创伤后应激障碍密切相关(荟萃分析，见Orth&Wieland，2006)；ii)对患有战斗相关创伤后应激障碍的个体危害特别大(Novaco&Chemtob，2002年)；以及iii)有效治疗战斗相关创伤后应激障碍的关键障碍(福布斯等人，2003年；福布斯等人，2008年)。尽管愤怒和攻击对患有创伤后应激障碍的退伍军人的生活产生了有害的影响，尽管愤怒和攻击对治疗和康复构成了障碍，但人们对创伤后应激障碍中潜在的人际攻击的神经行为病理，或者患有创伤后应激障碍的个体进行更广泛的合作互动的能力了解很少。拟议研究的广泛目标是解决这些领域的问题。也就是说，我们寻求确定攻击的客观行为和神经指标，这些指标有助于与战斗相关的创伤后应激障碍患者的社会互动受损。为了实现这一目标，拟议的项目寻求：7量化患有创伤后应激障碍的退伍军人和与战斗匹配的对照退伍军人在攻击性和非攻击性人际交流过程中的行为决定和相关的神经活动。7量化患有创伤后应激障碍的退伍军人和战斗匹配的对照退伍军人在合作和非合作人际交流过程中的行为决定和相关的神经活动。7探讨创伤后应激障碍患者在攻击性和合作性方面的诊断差异是否与理解社会伴侣的想法和意图相关的神经结构功能减弱有关。制定与战斗相关的创伤后应激障碍相关人际关系困难的客观神经行为测量将有助于及早识别需要治疗的退伍军人，并可能有助于设计和实施有针对性的治疗干预措施。

DESCRIPTION (provided by applicant): ABSTRACT Anger and aggression are serious and frequent complicating factors in the treatment of post-traumatic stress disorder (PTSD). A host of studies now demonstrate that interpersonal aggression and anger are: i) strongly associated with post-traumatic stress disorder (for meta-analysis, see Orth & Wieland, 2006); ii) particularly pernicious among individuals with combat-related PTSD (Novaco & Chemtob, 2002); and, iii) critical barriers to effective treatment in combat-related PTSD (Forbes et al., 2003; Forbes et al., 2008). Despite the detrimental impact that anger and aggression have on the lives of combat veterans with PTSD, and despite the barrier that anger and aggression pose to treatment and recovery, very little is understood about the neurobehavioral pathology underlying interpersonal aggression in PTSD, or the capacity of individuals with PTSD to engage in cooperative interactions more generally. The broad goal of the proposed research is to address these areas. That is, we seek to identify objective behavioral and neural metrics of aggression that contribute to impaired social interactions of individuals with combat- related PTSD. To achieve this goal, the proposed project seeks to: 7 Quantify behavioral decisions and associated neural activity during aggressive and non- aggressive interpersonal exchanges among veterans with PTSD and combat-matched control veterans. 7 Quantify behavioral decisions and associated neural activity during cooperative and non- cooperative interpersonal exchanges among veterans with PTSD and combat-matched control veterans. 7 Explore whether diagnostic differences in aggression and cooperation in PTSD are related to diminished function of neural structures associated with understanding the thoughts and intentions of social partners. The development of objective neurobehavioral measures of interpersonal difficulties associated with combat-related PTSD will facilitate early identification of veterans in need of treatment, and may aid in design and implementation of targeted therapeutic interventions.