CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource

CNS HIV抗逆转录病毒治疗效果研究（CHARTER）于2002年资助，目的是探索在高效抗逆转录病毒治疗（HAART）的背景下HIV神经系统并发症的变化。CHARTER的六个执行地点（约翰霍普金斯大学、西奈山医学院、加州大学圣地亚哥分校、德克萨斯大学加尔维斯顿分校、华盛顿大学、圣路易斯华盛顿大学）能够标准化神经医学、神经心理学、精神病学、神经病变和成像协议以及持续的质量保证程序。CHARTER项目得出的两个关键结论是，尽管有效的艾滋病毒治疗显著降低了死亡率和非神经系统发病率，但艾滋病毒相关神经认知障碍（HAND）和周围神经病变仍然非常普遍。CHARTER项目收集了674名参与者的纵向数据，积累了宝贵的临床和研究数据。数据包括神经医学特征、神经心理功能、精神病学和药物滥用变量、治疗数据、脑成像以及病毒和宿主遗传信息。每次CHARTER访问产生大约4000个独立变量；目前，该数据库包含超过500万个数据点。CHARTER项目的一个关键组成部分是通过向调查人员提供这一丰富的样本和数据，促进进一步的研究和分析。为了继续向神经艾滋病社区提供样本和数据集，CHARTER作为一种资源将通过以下方式得到加强：1) CHARTER Imaging Utilities；2)促进跨机构协作的文档协作工具（例如，签入/签出系统，变更跟踪和自动文档备份）；3)增强用户管理（例如，访问仓库数据和基于社区的公用事业，以促进跨机构协作）；4)数据字典增强。此外，CHARTER作为一种资源将征求用户的反馈，以进一步提高资源效用。这些增强将补充精心构建和建立的机制：a)宣布资源的可用性，b)征求请求，c)促进对所有请求的科学审查，以及d)处理和分发样本和数据给科学请求者。

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in 2002 with the aim of exploring the changing presentation of HIV neurological complications in the context of Highly Active Antiretroviral Therapy (HAART). The six performance sites of CHARTER (Johns Hopkins University, Mt. Sinai Medical School, University of California at San Diego, University of Texas Medical Branch at Galveston, University of Washington, Washington University at St. Louis), were able to standardize neuromedical, neuropsychological, psychiatric, neuropathy, and imaging protocols along with on-going quality assurance procedures. Two key conclusions to emerge from the CHARTER project are that HIV-Associated Neurocognitive Disorders (HAND) and peripheral neuropathy remain highly prevalent despite effective HIV treatments that have significantly reduced mortality and non-neurologic morbidities. The CHARTER project has accumulated invaluable clinical and research data with longitudinal data being collected on 674 participants. Data includes neuromedical characterization, neuropsychological functioning, psychiatric and drug abuse variables, treatment data, brain imaging, and viral and host genetics information. Each CHARTER visit generates approximately 4000 individual variables; currently the database contains over 5 million data points. A key component of the CHARTER project is to serve as a catalyst for additional studies and analyses by making this wealth of samples and data available to investigators. In order to continue to make samples and data sets available to the NeuroAIDS community, ¿CHARTER as a Resource¿ will be enhanced with the following; 1) CHARTER Imaging Utilities; 2) Document Collaboration Utilities to facilitate cross institutional collaboration (e.g., check-in/check-out systems, change tracking and automated document back-ups); 3) User Management Enhancements (e.g., access to warehoused data and community based utilities to foster cross institutional collaboration); and 4) Data Dictionary Enhancements. In addition, CHARTER as a Resource will solicit feedback from users to further enhance the Resource utilities. These enhancements will complement carefully constructed and established mechanisms for a) announcing the availability of the resource, b) soliciting requests, c) facilitating scientific review of all requests, and d) processing and distributing samples and data to scientific requestors.