Case Urology Translational Research Training Program (CUTRTP)

描述（由申请人提供）：泌尿系统疾病，包括生殖泌尿系统疾病（GU），可以是先天性的或获得性的，恶性的或良性的，内科的或外科的。2000年大约有超过2500万的医生和医院就诊仅仅是前四种泌尿系统疾病；然而，解决这些问题的研究组合滞后。大多数专家认为，缺乏合格的科学家和泌尿科专家是最重要的因素。因此，凯斯西储大学（CWRU）医学中心泌尿学研究所（CWRU UI）的创建，其总体目标是快速扩展转化研究和培训新一代科学家和外科科学家。通过本提案所要求的资金，我们建议建立CWRU泌尿外科转化研究培训计划（CUTRTP），以扩大我们目前对每年培养2至6名博士后博士或研究生医学博士（5年共12人）的支持，分为科学家（博士或医学博士候选人）和外科科学家（医学博士候选人）两个方向。所有候选人必须有强烈的愿望追求学术医学的职业生涯，专注于转化研究。理想的成功博士候选人将完成他们的培训，并可能有0-1年的博士后工作。理想的成功的医学博士候选人将获得他们的医学博士学位，并在ACGME认可的项目中完成泌尿外科，妇科或家庭医学的住院医师，并有研究历史。CUTRTP以3个培训支柱为基础：1)为学员提供基础和临床导师的转化重点，以提高患者护理和结果的影响；2)从CWRU其他领域招募顶尖研究人员作为未来研究人员的培训师；3)教学和专业培训，具有里程碑，由独立评估委员会评估。使用结构化课程，我们建议培训一批科学家和外科科学家，专注于3个主要领域的转化泌尿学研究：a)泌尿生殖系统癌症，b)女性盆底疾病，c)肥胖和糖尿病的泌尿系统并发症。所有受训者将在他们2年的专注研究中获得相同水平和承诺的指导，并且必须与其他合格的受训者竞争第二年的职位。由来自15个科室的29名优秀培训师组成的小组，获得了美国国立卫生研究院总计约3000万美元的资助，共同参与了CUTRTP项目，以确保泌尿系统疾病领域一些最优秀的科学家和外科医生的选择、招募、培训和输送。

DESCRIPTION (provided by applicant): Urological diseases which include conditions of the genito-urinary tract (GU) can be congenital or acquired, malignant or benign, and medical or surgical. Roughly more than 25 million visits to physicians and hospitals took place in 2000 for just the top 4 urologic conditions; however, the research portfolio to address them lags. Most experts would consider the shortage of qualified scientists and urologists-scientists as the most important contributing factor. Thus, the Urology Institute of the Case Western Reserve University (CWRU) Medical Center (CWRU UI) was created with the overarching goal of rapid expansion of translational research and training of a new generation of scientists and surgeon-scientists. Through the funding requested in this proposal we propose to establish the CWRU Urology Translational Research Training Program (CUTRTP), to expand our current support for the training of 2 to 6 postdoctoral PhD or postgraduate MDs, per year (12 total over 5-years), in two tracks of scientists (for Ph.D. or M.D. candidates) and surgeon-scientists (for MD Candidates). All candidates must have a strong desire to pursue a career in academic medicine focusing on translational research. The ideal successful PhD candidates will have completed their training and potentially, 0-1 years of postdoctoral work. The ideal successful MD candidates will have received their MD and completed residency in urology, gynecology, or family medicine at an ACGME accredited program, and have a history of research. The CUTRTP is based on 3 training pillars: 1) a translational focus for trainees with basic and clinica mentors to yield greater impact on improved patient care and outcomes 2) recruitment of the top researchers from other fields at CWRU as trainers of future investigators, 3) didactic and professional training, with milestones, evaluated by an independent Evaluation Committee. Using a structured curriculum, we propose to train a group of scientists and surgeon-scientists to focus on translational urology research in 3 main areas: a) genitourinary cancers, b) female pelvic floor disorders, and c) urological complications of obesity and diabetes. All trainees will receive the same level and commitment of mentoring throughout their 2 years of devoted research and must compete for the 2nd year position with other qualified trainees. A group of 29 outstanding trainers from 15 departments with a cumulative NIH-funding total of approximately $30 million have come together in the CUTRTP to ensure selection, recruitment, training, and delivery of some of the best scientists and surgeon-scientists in urological diseases.