PDT Physics Core

PDT物理核心的目标是：1)为所有项目提供激光和其他光源支持；2)为项目(1、3、4和5)提供高质量和可靠的在体光剂量学；3)为所有项目提供绝对光剂量学标准；4)为PDT治疗前、后和期间的组织光学性质、药物浓度和组织氧合提供明确的PDT剂量学。 物理核心负责校准激光光源的绝对输出功率，确保它们可追溯到美国国家科学技术研究所(NIST)维护的标准。该核心在体内进行光剂量学，以实现在PDT治疗中准确的光通量测量，例如腹膜内和胸膜PDT研究。维持在PDT治疗波长(532-730 nm)下运行的激光设备，以及覆盖吸收和荧光光谱波长在400-900 nm之间的光源。物理核心将在体内PDT剂量测定的物理项目中开发的光谱技术转化为临床试验。物理核心确保激光安全，维护物理设备的质量保证，并致力于表征组织中的光通量分布。它有助于将物理项目(项目4)中开发的有用技术应用到常规临床应用中。

The goals of the PDT Physics core are to: 1) Provide Laser and other light source support for all projects; 2) Perform high-quality and reliable in vivo light dosimetry for projects (1,3,4 and 5); 3) Provide absolute light dosimetry standards for all projects; 4) Provide explicit PDT dosimetry for tissue optical properties, drug concentrations, and tissue oxygenation before, after, and during PDT. The physics core is responsible for calibrating the absolute output power of laser sources, ensuring that they are traceable to standards maintained by the National Institute of Science and Technology (NIST). The core performs in vivo light dosimetry to achieve accurate light fluence measurement in PDT treatments, such as the Intraperitoneal and Pleural PDT studies. Laser equipment operating at treatment wavelengths (532-730 nm) for PDT are maintained, along with light sources covering wavelengths between 400 - 900 nm for absorption and fluorescence spectroscopy. The physics core translates the spectroscopic techniques developed in the physics project for in vivo PDT dosimetry into clinical trials. The physics core ensures laser safety, maintains quality assurance of physics equipment, and works to characterize light fluence distributions in tissue. It helps to implement useful technologies developed in the physics project (Project 4) to routine clinical applications.