CMPB Central Pathology Support

CMPB病理核心实验室继续为研究所内60多个研究实验室提供重要的病理支持服务、合作和咨询。在过去的一年里，以协作和支持为导向的工作对一系列研究项目产生了重大影响，这些研究项目涉及对各种疾病和疾病过程的研究和理解，如心血管疾病（动脉粥样硬化）、炎症性呼吸系统疾病、肥胖和II型糖尿病、炎症和免疫介导的肾脏疾病、基因表达和基因调控、轴向骨骼发育、癌症和饮食限制的跨代影响。所有核心实验室的工作量和工作范围都显著增加，与科学工作人员的合作和协商也有所增加，无论是在技术层面上关于所需方法，还是在科学层面上，需要与工作人员病理学家进行协商。核心工作人员与调查人员合作，为各种应用开发和建立专门的技术和协议。此外，使用来自DNTP亚慢性（90天）和慢性（2年）生物测定的材料，core已经参与了旨在阐明各种增生性非肿瘤性肿瘤病变发展的发病机制和分子机制的回顾性研究。

The CMPB Pathology Core Laboratories have continued to provide critical pathology support services, collaboration and consultation for over 60 research laboratories across the Institute. Over the past year, collaborative and support oriented work has had a significant impact on a spectrum of research programs involved in the study and understanding of a variety of diseases and disease processes such as cardiovascular disease (atherosclerosis), inflammatory respiratory disease, obesity and type II diabetes, inflammatory and immune-mediated renal disease, gene expression and gene regulation, axial skeletal development, cancer and transgenerational effects of diet restriction. The volume and scope of work has increased significantly across all of the Core Laboratories, as have collaborations and consultations with scientific staff whether on a technical level regarding the methods required, or on a scientific level, requiring consultation with a staff pathologist. Core staff have worked with investigators to develop and establish specialized techniques and protocols for a variety of applications. Additionally, using materials from the DNTP subchronic (90-day) and chronic (2-year) bioassays, the Cores have been involved in retrospective studies aimed at elucidating the pathogenesis and molecular mechanisms involved in the development of variety of proliferative non-neoplastic neoplastic lesions.