COBRE for the Center for Molecular Medicine

描述（由申请人提供）：本COBRE III期提案旨在进一步发展肯塔基州大学的分子医学中心。该中心专注于旨在了解与人类疾病相关的分子机制的研究，重点是癌症，神经退行性疾病，糖尿病和心血管疾病。我们建议过渡到独立的研究基础设施在以前的COBRE资助。我们的COBRE资助的分子医学中心已经取得了一些成功。在上一个资助期间，来自12个不同部门和中心的30名初级教师作为COBRE项目或试点赠款PI获得资助。这些指导教师获得了27个NIH ROI赠款，11个其他NIH赠款和41个其他同行评审的校外赠款。COBRE-supported初级教师发表了400多篇研究论文。这些和其他成功在很大程度上可以归因于一个强大的辅导计划，优秀的机构支持，以及与中心相关的科学核心的可用性。为此，我们建议将分子医学中心及其三个科学核心转变为独立于NIH/NIGMS的支持，并加强和升级核心技术。值得注意的是，我们的两个原始核心已经或很快将过渡到独立; 由该COBRE开发的蛋白质组学核心现在是大学的收费服务核心，而COBRE支持的成像核心很快将成为部门支持的核心。在拟议的五年过渡期内，我们将增加与中心相关的教师的临界质量，并继续加强其核心。使用凭单将促进核心用途，试点赠款将发展研究合作和竞争性赠款提交。行政核心将作为赠款的协调中心，并与计划协调员和内部咨询委员会一起作为中心的业务部门。一个由世界知名科学家组成的外部咨询委员会将对中心进行持续的评估和评价。持续的机构承诺将确保方案增长和长期可持续性。

DESCRIPTION (provided by applicant): This COBRE Phase III proposal aims to further develop the Center for Molecular Medicine at the University of Kentucky. This Center focuses on research aimed at understanding the molecular mechanisms associated with human disease with emphases on cancer, neurodegenerative diseases, diabetes, and cardiovascular diseases. We propose to transition to independence the research infrastructure developed during previous COBRE funding. Our COBRE funded Center for Molecular Medicine has had a number of successes. During the previous funding period 30 junior faculty from 12 different departments and centers were funded as COBRE project or pilot grant PIs. These mentored faculty received 27 NIH ROI grants, 11 other NIH grants, and 41 other peer-reviewed extramural grants. The COBRE-supported junior faculty published more than 400 research papers. These and other successes can in large part be attributed to a strong mentoring program, excellent institutional support, and the availability of the scientific cores associated with the Center. For this application, we propose to transition the Center for Molecular Medicine and its three scientific cores to independence of NIH/NIGMS support and to enhance and upgrade core technologies. It is worth noting that two of our original cores have or soon will transition to independence; the Proteomics core developed by this COBRE is now a University fee-for-service core, and the COBRE supported Imaging core is soon to become a department supported core. During the proposed five-year transition period we will increase the critical mass of faculty associated with the Center and continue to enhace its Cores. The use of vouchers will promote core usage and pilot grants will develop research collaborations and competitive grant submissions. The Administrative Core will serve as the focal point of the grant and in conjunction with the Program Coordinator and Internal Advisory Committee will serve as the operational arm of the Center. An External Advisory Committee, consisting of world-renown scientists will provide ongoing assessment and evaluation of the Center. Continuing Institutional commitments will ensure programmatic growth, and long-term sustainability.