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Genetic insights into atherosclerosis

Genetic insights into atherosclerosis
动脉粥样硬化的遗传学见解
批准号：
8746627
负责人：
PAUL M. HWANG
金额：
$40.17万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8746627
关键词：
AffectArterial Fatty StreakAtherosclerosisBloodBlood specimenCell RespirationCholesterolGeneticGenetic ModelsGenetic ScreeningGenomicsGrantHumanImmune systemInflammationLegal patentMediator of activation proteinOxidative StressProteinsRheumatoid ArthritisSeverity of illnessSignal TransductionTIS11 proteinTechniquesTissue SampleTissuesZinc Fingershuman subjectinsightinterestnovel

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中文摘要
翻译
通过我们使用人类血液和动脉粥样硬化斑块组织样本的基因组研究，我们已经确定了动脉粥样硬化疾病严重程度的标志物和他汀类药物治疗的胆固醇非依赖性标志物，并已获得使用专利。 我们还鉴定了tristetraprolin锌指蛋白36（TTP）作为炎症性关节炎和动脉粥样硬化的重要的局部组织炎症的介质。 随着我们对影响炎症（动脉粥样硬化的驱动因素）的氧化应激和代谢的兴趣，我们正在进行研究，以使用特定的遗传模型来检查改变的p53信号传导对免疫系统的影响。
英文摘要
Through our genomic studies using human blood and atherosclerotic plaque tissue samples, we have identified a marker of atherosclerosis disease severity and a cholesterol-independent marker of statin treatment, which has been granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. With our interest in oxidative stress and metabolism which affect inflammation, a driver of atherosclerosis, we are pursuing studies to examine the effect of altered p53 signaling on the immune system using specific genetic models.
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