Training Program in Molecular Oncology and Immunology

描述(由申请者提供)：本提案要求资金继续支持我们在分子肿瘤学和免疫学方面的综合培训计划。我们请求支持对5名博士后和10名博士后研究员(博士、医学博士或医学博士/博士)进行分子肿瘤学和免疫学综合学科的培训。培训侧重于这一跨学科领域的综合教育，使受训者更好地了解细胞转化、生长控制、肿瘤启动和进展以及免疫反应所涉及的调控机制。该计划的一个特别重点是改善癌症诊断和治疗的翻译方法。这些学科的交叉受精可以开发出全新的方法来研究原癌基因和免疫相关细胞和组织在正常状态和肿瘤情况下的研究，促进癌症翻译研究的发展。该计划的独特之处在于，学员精通免疫学和分子肿瘤学的基础知识；学员在临床环境中接触到大量的癌症研究；学员有机会对癌症相关项目进行深入研究；学员精通对当前文献的批判性评估、实验数据的分析和研究结果的陈述；所有学员都接受负责任的研究行为教育。来自病理学、细胞生物学、生物化学、药理学、医学系、儿科、泌尿科、放射肿瘤科、皮肤科、放射科和微生物系的39名教职员工作为主要导师参加了这个项目，他们还得到了一批临床医生-教育家的补充，他们是副学院。该项目由萨克勒基础医学研究所和纽约大学癌症研究所支持，并充分利用纽约大学医学院广泛的基础和临床癌症研究基础设施，让学员密切参与尖端癌症研究的实践和智力严谨。

DESCRIPTION (provided by applicant): This proposal requests funds for continued support of our comprehensive training program in molecular oncology and immunology. We request support to training 5 predoctoral and 10 postdoctoral fellows (PhD, MD or MD/PhD) in the integrated discipline of molecular oncology and immunology. Training focuses a combined education in this interdisciplinary area, to provide trainees with a better understanding of the regulatory mechanisms involved in cellular transformation, growth control, tumor initiation and progression, and immunological responses. A particular focus of the program is on translational approaches to improved cancer diagnosis and treatment. Cross-fertilization of these disciplines allows development of entirely new approaches to study both proto-oncogenes and immunologically relevant cells and tissues in their normal state as well as in neoplastic situations, fostering the development of translational research in cancer. The unique aspects of this program are that trainees become proficient in the basics of both immunology and molecular oncology; the students receive a significant exposure to cancer research in a clinical setting; the students have the opportunity for in-depth research on a cancer related project; the trainees become proficient in critical evaluation of the current literature, analysis of experimental data, and presentation of the results of research; and all trainees are educated in the responsible conduct of research. Thirty-nine faculty members from the Departments of Pathology, Cell Biology, Biochemistry, Pharmacology, Medicine, Pediatrics, Urology, Radiation Oncology, Dermatology, Radiology and Microbiology participate as primary mentors in this program, and they are supplemented with a committed set of clinician-educators as Associate Faculty. The program is under the aegis of the Sackler Institute for Basic Medical Sciences and the New York University Cancer Institute and makes full use of the extensive basic and clinical cancer research infrastructure of New York University School of Medicine to intimately involve trainees in both the practical and the intellectual rigors of cutting-edge cancer research.