Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT)

描述（由申请人提供）：通过我们强大的指导计划，出色的设施开发和出色的外部咨询小组审查，我们在全国唯一的生物工程COBRE的第一阶段资助期间取得了显着的成功。从只有四个项目开始，我们的项目已经扩展到支持和指导13名初级教师，他们共同获得了超过1000万美元的外部资金，并发表了151篇期刊文章。其中五个国家还获得了独立地位。通过这笔COBRE资金，我们已经招募了三名初级和两名高级生物工程教师。克莱姆森为试点项目提供了成本分摊支持，并大幅扩大了核心设施，最引人注目的是与格林维尔医院系统建立了一个新的生物工程创新园区（CUBEInC，1600万美元）。CUBEInC，29，000平方米英尺为研究者和临床医生提供实验室和网络空间，一个外科技能设施， 会议中心，将作为我们的第二阶段COBRE倡议的新网站。2012年，一座新的生物工程大楼也在查尔斯顿的MUSC校园落成。这个耗资6000万美元的新设施代表了全州对生物工程和再生医学的日益重视，并容纳了五名全职克莱姆森终身教职员工的实验室，其中一人是本次更新申请的目标PI。通过第一阶段的COBRE资金，克莱姆森光成像设施（CLIF）现在是在新的生命科学建设克莱姆森校园的指导下博士。在第二阶段，我们将在这些成功的基础上再接再厉。我们将通过我们的南卡罗来纳州组织再生和形成生物工程中心（SC BioCRAFT），在我们的组织工程研究中扩展基于生物材料的方法，以更基本地分析组织再生和形成。我们已经选择了五名新的杰出研究人员（其中3名在COBRE第一阶段雇用），并提供启动资金，以发展他们在第二阶段的研究。我们还整合并增加了新的核心专业领域。我们提出了一个独特的生物工程和生物成像（B5）核心和细胞，组织和分子分析（CTMA）核心设施，以支持在国家初级教师。 该提案描述了我们建立有效科学合作的计划，以维持SC BioCRAFT超过P20资金，同时加强我们州和全国的生物工程和组织再生科学界。我们的具体目标是：1）通过指导另外五名具有与我们的主题相关的兴趣和才能的杰出目标研究者的研究职业发展，扩大与COBRE相关的受资助研究者的临界质量; 2）加强我们的核心，以帮助我们的目标教师成功地竞争国家卫生研究院的资金，并与全州的研究人员建立合作，包括COBRE毕业生和具有相关兴趣的非COBRE研究人员; 3）促进SC BioCRAFT作为指定的，可持续的大学认可的研究中心的正式认可，以支持从COBRE过渡到来自不同联邦和非联邦来源的长期竞争支持。

DESCRIPTION (provided by applicant): Through our strong mentoring plan, excellent facility development, and outstanding external advisory panel review, we have achieved remarkable success during the Phase I funding of the only bioengineering COBRE in the nation. Begun with only four projects, our program has expanded to support and mentor 13 junior faculty who have collectively received >$10M in external funding, and published 151 journal articles. Five have also received independent status. Through this COBRE funding, we have recruited three junior and two senior BioE faculty. Clemson has provided cost-share support for pilot projects and a significant expansion of core facilities, most notably a new bioengineering innovation campus (CUBEInC, $16M) with the Greenville Hospital System. CUBEInC, with 29,000 sq. ft. of laboratory and networking space for investigators and clinicians, a surgical skills facility, and a conference center, will serve as the new site for our Phase II COBRE initiative. A new bioengineering building was also opened on the MUSC campus in Charleston in 2012. This new $60M facility represents the growing statewide emphasis on bioengineering and regenerative medicine and houses the labs of five full time Clemson tenure track faculty, one of whom is the target PI in this renewal application. Through Phase I COBRE funding, the Clemson Light Imaging Facility (CLIF) is now in the new Life Sciences building on the Clemson campus under the direction of Dr. Terri Bruce, our core director. We will build on these successes in Phase II. We will expand upon biomaterials-based approach in our tissue engineering studies to a more fundamental analysis of tissue regeneration and formation through our South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT). We have selected five new outstanding investigators (3 hired during COBRE Phase I) and provided startup funds to develop their research in Phase II. We have also consolidated and added new areas of core expertise. We propose a unique Bioengineering and Bioimaging (B5) Core and Cell, Tissue, and Molecular Analysis (CTMA) core facilities to support junior faculty in the state. This proposal describes our plan to build an effective scientific collaboration to sustain the SC BioCRAFT beyond P20 funding while strengthening the bioengineering and tissue regeneration scientific community in our state and nationally. Our specific aims are to 1) expand the critical mass of funded investigators affiliated with the COBRE through mentoring in research career development of five additional outstanding targeted investigators with interests and talents relevant to our theme; 2) enhance our core to help our targeted faculty compete successfully for NIH funding and forge collaborations with investigators statewide, including COBRE graduates and non-COBRE researchers with relevant interests and; 3) Promote formal recognition of SC BioCRAFT as a designated, sustainable University recognized research center to support the transition from COBRE to long-term competitive support from diverse federal and non-federal sources.