Biomedical Alcohol Research Training Program

请参阅说明)： 生物医学酒精研究培训计划将培养年轻的博士前博士和医学/博士相结合的博士 拥有MD、DVM和/或博士学位的学生和博士后研究员，从事生物医学方面的研究 酒精消费和滥用的后果。核心学院将主要负责指导学员和 包括18名科学家：洛杉矶新奥尔良LSUHSC医学院(13名)和公共卫生学院(2名)；杜兰 位于洛杉矶卡温顿的国家灵长类动物研究中心(1)和巴吞鲁日的LSD兽医学院， La(2)。培训计划还依赖LSUHSC(8)和TNPRC(5)的13个支持学院，他们共同担任 指导和提供不同领域的酒精研究和专业培训，如实验设计 并在研究中对动物进行统计分析和使用。学员将在四岁以下从事酒精研究项目 相关主题1)酒精/艾滋病毒疾病，2)酒精/宿主免疫反应，3)酒精/神经内分泌和 行为。该培训计划旨在培养学员的技术、研究开发和沟通能力 技能，使他们能够通过进行假说驱动的机制研究来推动知识的发展 酒精消费和滥用对1)感染背景下的先天和特定免疫系统，2) 猴免疫缺陷病毒病在非人类中的传播、发病机制、进展及治疗 灵长类动物，3)抗逆转录病毒治疗的疗效和副作用，4)肝脏产生自由基的机制，包括 P450酶系统和宿主防御系统的细胞，5)SIV背景下的学习/记忆获得 疾病和神经递质控制，6)创伤引起的神经内分泌和心血管功能的改变以及 7)SIV或细菌感染和创伤的造血改变。实习生的发展将通过他们的 参加一个职业发展计划，旨在增加他们在酒精方面的知识基础 研究领域，对实验设计和分析的理解，专业精神，进行的制度要求 研究以及他们的书面和口头沟通能力。在此资助期间，5名博士后实习生在 博士、医学博士组合项目或系博士项目和4名博士后研究员 博士)将在每年的计划中。努力继续我们在培训来自不同领域的研究员方面的成功 将强调在生物医学研究领域中代表性不足的背景。该计划的目标是 提供指导和重点培训，使年轻的医学博士和博士科学家能够熟悉 与酒精消费相关的生物医学问题，并获得进行高质量、有竞争力的研究的工具。 相关性(请参阅说明)： 这笔培训赠款将通过培训新的基础和临床科学家来满足我国的卫生需求。它 这一点很重要，因为我们国家正面临着进入生物医学研究领域的美国公民的严重短缺。在……里面 具体地说，该计划将培训有抱负的科学家开发关于主要健康问题的研究计划， 酒精使用障碍的生物医学后果，如肝病、胎儿酒精综合征、肺炎和艾滋病毒 疾病。在美国，酒精每年导致约12万人过早死亡，并对人们的生活产生不利影响 在大约1400万符合酒精滥用诊断标准的美国人及其家庭成员中 给社会带来了超过2000亿美元的医疗费用。

See instructions): The Biomedical Alcohol Research Training Program will prepare young predoctoral PhD and combined MD/PhD students, and postdoctoral fellows with MD, DVM and/or PhD degrees for research careers on the biomedical consequences of alcohol consumption and abuse. Core Faculty will be primarily responsible for mentoring trainees and include 18 scientists: School of Medicine (13) and School of Public Health (2) at LSUHSC in New Orleans, LA; Tulane National Primate Research Center in Covington, LA (1), and the School of Veterinary Medicine at LSD in Baton Rouge, LA (2). The Training Program also relies on 13 Support Faculty from LSUHSC (8) and the TNPRC (5) who serve as co- mentors and provide expertise on diverse areas of alcohol research, and specialty training such as experimental design and statistical analysis and use of animals in research. Trainees will pursue alcohol research projects under four interrelated themes 1) Alcohol/HIV Disease, 2) Alcohol/Host Immune Response, 3) Alcohol/Neuroendocrine and Behavior. The Training Program is designed to develop in trainees technical, research development and communication skills that will allow them to advance knowledge by conducting hypotheses-driven mechanistic research on the effect of alcohol consumption and abuse on 1) the innate and specific immune system in the context of infection, 2) the transmission, pathogenesis, progression and treatment of simian Immunodeficiency virus disease in nonhuman primates, 3) antiretroviral therapy efficacy and side effects, 4) mechanisms of free radical production by liver including the P450 enzyme system and by cells of the host defense system, 5) learning/memory acquisition in the context of SIV disease and neurotransmitter control, 6) trauma induced alterations in neuroendocrine and cardiovascular function and 7) hematopoietic changes to SIV or bacterial infection and trauma. Trainee development will be enriched by their participation in a professional development program that is designed to increase their knowledge base in the alcohol research field, understanding of experimental design and analysis, grantsmanship, institutional requirement to conduct research as well as their written and oral communication skills. During this funding period, 5 predoctoral trainees in either the PhD, MD combined program or departmental PhD programs and 4 postdoctoral fellows MD, DVM and/or PhD) will be in the Program each year. Efforts to continue our successes at training research fellows from diverse background that are under-represented in the biomedical research field will be emphasized. The goal of the program is to provide mentorship and focused training so that young MD and PhD scientists can become familiar with the biomedical problems related to alcohol consumption and acquire the tools to do high quality, competitive research. RELEVANCE (See instructions): This training grant will address the health needs of our nation through its training of new basic and clinical scientists. It is important because our nation is facing a critical shortage of US citizens entering the biomedical research field. In particular, this program will train aspiring scientists to develop research programs on a major health concern, the biomedical consequences of alcohol use disorders such as liver disease, fetal alcohol syndrome, pneumonia and HIV disease. In the U.S., alcohol causes premature death in about 120,000 people annually and adversely affects the lives of approximately 14 million Americans that meet diagnostic criteria for alcohol abuse as well as their family members at a health care cost to society of greater than $200 billion dollars.