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Effects of redox homeostasis on cancer and cardiovascular diseases

Effects of redox homeostasis on cancer and cardiovascular diseases
氧化还原稳态对癌症和心血管疾病的影响
批准号：
8939832
负责人：
PAUL M. HWANG
金额：
$58.39万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8939832
关键词：
AerobicAffectBiologyCardiovascular DiseasesCardiovascular systemCell modelCellular StressDNA DamageDevelopmentEnergy MetabolismGeneticGenomic DNAHealthHomeostasisHumanLifeMalignant NeoplasmsMethodsMitochondriaNuclearOxidation-ReductionOxygenPathogenesisReactive Oxygen SpeciesStressmitochondrial dysfunctionmouse modelneoplastic cellpreventtumorigenesis

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中文摘要
翻译
我们以前的研究表明，线粒体功能障碍会导致氧化基因组DNA损伤，并有助于肿瘤的发生。氧也是形成活性氧物种的重要底物，但它也是有氧生命所必需的。我们目前正在使用环境和遗传方法来调节氧稳态，并检查它们对能量代谢和肿瘤发生的影响。我们还在研究肿瘤或心血管来源的细胞在氧化或其他毒性应激条件下存活的适应机制。
英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. Oxygen also serves as an essential substrate for reactive oxygen species formation but it is also essential by aerobic life. We are currently using environmental and genetic methods to modulate oxygen homeostasis and to examine their effect on energy metabolism and tumorigenesis. We are also examining adaptive mechanisms by which cells of neoplastic or cardiovascular origin survive under oxidative or other toxic stress conditions.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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