Interactions between the ? and ? subunits of the DHPR - a missing link in skeletal muscle excitation-contraction coupling and a role in sarcopenia

钙信号在肌肉疾病中被破坏，包括老年人的肌肉无力。这是一个严重的问题，因为所有的活动都依赖于钙信号，而钙信号的中断可能会导致严重的残疾和死亡。为了减轻钙信号的缺陷，必须充分了解潜在的分子机制，但我们对这些过程只有一个大致的轮廓。我们将解决这一问题，为缓解年龄相关性肌肉无力提供一个平台。

Calcium signaling is disrupted in muscle diseases, including muscle weakness in the elderly. This is a significant problem as all mobility depends on calcium signaling and its disruption can cause serious disability and death. To alleviate defective calcium signaling, the underlying molecular machinery must be fully understood, yet we have only a broad outline of the processes. We will address this problem to provide a platform for alleviating age-related muscle weakness.