Secondary Analyses of Adolescent Caries, Including Fluoride, Diet & Other Factors

在理论确认糖在龋齿病因学中的突出作用一个世纪后，这一发现 在氟化物的有益影响中，龋病在整个儿童时期仍然是一种高度流行的疾病，包括 青春期。青少年更独立，经常接触含糖饮料(如苏打水 似乎将他们置于比更年轻的年龄更大的风险中。然而，这些龋齿发病模式和 与风险因素的关系知之甚少，因为关于龋齿发病率或风险的研究很少。 青春期受试者的影响因素。自1991年以来，使用出生时招募的队列，正在进行的爱荷华州氟化物 研究(IFS)全面评估了饮食数据和氟暴露之间的关系以及 5岁、9岁和13岁的人患龋齿。由于龋病仍然是青少年的一种重要疾病， 拟议的研究提供了一个独特的机会来评估社会人口、饮食、氟化物、 等因素影响13~17岁青春期患龋率。 这项建议的主要目标是：1)对牙科类型进行详细的二次分析 17岁恒牙期龋病及13~17岁患龋率；2)综合 检查13至17岁的龋齿发病率(和17岁患病率)之间的关系以及 饮食、氟化物、龋齿病史和社会人口因素。多变量分析将评估 龋病结局之间的关系和相互作用(发病率/增量 流行率/计数)和纵向收集的各种饮食模式、口腔健康行为、氟化物的数据 暴露、既往龋齿经历、社会人口学和其他因素。然后，我们将评估 我们关于13-17岁儿童龋病危险因素的研究结果与龋病分析结果的一致性 5到9岁和9到13岁早期的风险因素。作为涉及招募和成功 从出生起就保留队列是极其罕见的，爱荷华州的氟化物研究提供了一个独特的机会来研究 这些关系以前所未有的细节，增强了我们发展有效青少年龋齿的能力 预防计划。

A century after theories identified the prominent roles of sugars in dental caries etiology and the discovery of the beneficial effects of fluorides, caries remains a highly prevalent disease throughout childhood, including adolescence. Adolescents' greater independence and frequent exposure to sugared beverages (e.g., soda pop) appear to place them at greater risk than at younger ages. However, these caries incidence patterns and relationships with risk factors are poorly understood because there are few studies of caries incidence or risk factors among adolescent subjects. Since 1991, using a cohort recruited at birth, the ongoing Iowa Fluoride Study (IFS) has comprehensively assessed the relationships between dietary data and fluoride exposures and dental caries in individuals at ages 5, 9, and 13. As caries continues to be a significant disease in adolescents, the proposed study provides a unique opportunity to assess the effects of socio-demographic, dietary, fluoride, and other factors on the incidence of dental caries during adolescence from age 13 to 17 years in our cohort. The main objectives of this proposal are to 1) conduct detailed secondary analyses of patterns of dental caries of the permanent dentition at age 17 and caries incidence from 13 to 17, and 2) comprehensively examine the relationships among dental caries incidence from age 13 to 17 (and age 17 prevalence) and dietary, fluoride, prior caries experience, and socio-demographic factors. Multivariable analyses will assess the relationships between and interactions among caries outcomes (incidence/increments and prevalence/counts) and longitudinally-collected data on various dietary patterns, oral health behaviors, fluoride exposures, previous caries experience, socio-demographics, and other factors. We will then assess the consistency of our findings concerning caries risk factors for ages 13 to 17 with those from analyses of caries risk factors during earlier periods from ages 5 to 9 and 9 to 13. As studies involving recruitment and successful retention of a cohort from birth are extremely rare, the Iowa Fluoride Study offers a unique opportunity to study these relationships in unprecedented detail, enhancing our ability to develop effective adolescent caries prevention programs.