Nephrology Training Grant

描述(由申请者提供)：此申请建议继续支持俄勒冈健康与科学大学成功的肾病学和高血压研究培训计划。这是该项目的第一次竞争性续签，目前已进入第四个年头，每年支持两名学员。它的首要目标是培养合格的博士后受训人员，使他们能够作为独立研究人员成功地从事科学事业；为了实现这一目标，它将在激励和合议的学术环境中提供关于假设驱动和假设生成、基础研究和疾病研究的强化培训。应聘者将拥有医学博士、医学博士或博士学位。成功的医学博士候选人将在参加本计划之前完成住院医师培训以及第一年的临床肾脏病研究员培训。这一要求允许医学博士和博士实习生将至少80%的时间投入到研究方面的第一手经验和培训上，并由一名成功的研究人员监督。研究活动将由一个结构化的教学计划补充，该计划包括每周一次的期刊俱乐部、进行中的研究会议、肾脏研究会议和正式的研究生水平的课程工作，这些工作是根据每个受训者的个人科学需求量身定做的。对于追求临床为导向的研究的受训者，教学计划预计将导致临床研究硕士学位。该计划的特殊优势包括：1)教师在及时领域的不同技能和研究兴趣，包括糖尿病肾病、慢性肾脏疾病、基于性别的肾脏疾病、高血压、离子和溶质运输、临床电解质浓度紊乱、移植医学和免疫生物学、蛋白质运输和脂质生物化学。临床研究兴趣包括：1)心血管疾病对肾移植的影响、高血压的分子机制以及农村地区慢性肾脏疾病护理的研究；2)OHSU临床和翻译科学奖(全国首批奖项之一)支持的近期扩大的临床研究资源，该奖项促进了尖端临床研究方面的培训；3)OHSU作为一所主要的研究型医学院的持续发展(2009年NIH资助的研究排名第23位)；4)已经开发的结构化的指导和评估模式，并将在下文列举。该培训计划的一个主要前提是，在未来几十年里，对熟练的医生和研究人员的需求只会继续增加，而且这种需求对于人类医疗保健的持续进步至关重要。好了！

DESCRIPTION (provided by applicant): This application proposes continued support for a successful research-based training program in Nephrology and Hypertension at Oregon Health & Science University. This is the first competing renewal for this program, now in its fourth year, supporting two trainees per year. Its overarching goal is to prepare qualified post doctoral trainees for successful scientific careers as independent investigators; to achieve this aim, it will provide intensive training in hypothesis-driven, and hypothesis generating, basic and disease-oriented research in a stimulating and collegial academic environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. Successful MD candidates will have completed residency training as well as a first, clinical, year of Nephrology fellowship training prior to enrolling in This Program. This requirement allows both MD and PhD trainees to devote at least 80% of their time to first-hand experience and training in research under the supervision of an established successful investigator. Research activities will be supplemented by a structured didactic program consisting of weekly journal clubs, research-in-progress meetings, Renal Research Conferences, and formal graduate level course work, tailored to the individual scientific needs of each trainee. For trainees pursuing clinically oriented research, the didactic program is expected to lead to a Master's Degree in Clinical Research. Special strengths of the program include: 1) The diverse skills and research interests of the faculty in timely areas including diabetic nephropathy, chronic kidney disease, gender-based kidney disease, hypertension, ion and solute transport, clinical disorders of electrolyte concentration, transplantation medicine and immunobiology, and protein trafficking and lipid biochemistry. Clinical research interests include patient-oriented outcomes research into effects of cardiovascular disease on renal transplantation, molecular mechanisms of hypertension, and chronic kidney disease care in rural areas, 2) the recently expanded clinical research resources supported by OHSU's Clinical and Translational Science Award (one of the first in the nation), which facilitates training in state-of-the-art clinical investigation; 3) continuing growth of OHSU as a major research-oriented Medical School (ranked 23rd in NIH funded research, 2009), and 4) the structured mentorship and evaluation model that has been developed and will be enumerated herein. A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades, and that this need is critical for continued advancements in human health care. !