Chemistry-Biology Interface Training Grant

描述（由申请人提供）：化学-生物学接口的这个令人兴奋的博士前培训项目涉及明尼苏达大学三个系的31名培训教师：化学、药物化学以及生物化学、分子生物学和生物物理学（BMBB）。CBITG在明尼苏达大学的使命是为学生提供跨越传统界限所需的技能，并在化学和生物学的界面理解和进行科学研究。这一使命将通过实现以下目标来完成：（一）通过涉及至少两个部门的课程组合，并通过涉及共同顾问和共同顾问实验室三个月研究经验的交叉培训经验，为学生提供化学和生物学接口的跨学科培训经验。(ii)通过专注于这种类型的界面科学（化学生物学座谈会）的研讨会，并允许他们组织自己的研讨会专注于化学生物学界面，让学生接触化学和生物学界面的前沿科学。(iii)通过为学员提供多种机会来展示他们的研究，包括在国家或国际会议上的演讲，提高学员的沟通技能。(iv)教育学生关于职业机会的范围可供科学家在这方面的培训。(v)通过与实习生、培训师和从事化学/生物学工作的杰出科学家的访谈，激发对我们培训计划的兴趣。(vi)增加在联合国从事研究的科学家的多样性， 化学和生物接口在我们的程序通过不同的推广活动相结合。学员将参与研究主题，包括：生物催化与生物分子设计（Distefano，Kazlauskas，Lipscomb，Ohlendorf，Schmidt-Dannert，Seelig Wackett，瓦格纳，威尔莫特），治疗剂（Aldrich，Amin，Bernlohr，Distefano，Georg，Harki，Haskell-Luevano，Hoye，Mansky，Tretyakova，瓦格纳，Xing），疾病化学（Aldrich，Arriaga，Bernlohr，Distefano，Harki，Haskell-Luevano，Mansky，Murphy，Pomerantz，Tretyakova，瓦格纳，Xing），金属生物化学（Amin，Lipscomb，Murphy，Ohlendorf，Pierre，Que，Wackett，威尔莫特）和生物分析/生物物理学（Arriaga，鲍泽，Griffin，Haynes，Pierre，Pomerantz，Tretyakova，托马斯，Veglia）。培训学院的研究小组都得到了很好的支持和装备。这个非常成功的培训计划已经持续了14年。在此期间，该方案每年要求为8名受训人员提供支助，每人支助两年。

DESCRIPTION (provided by applicant): This exciting pre-doctoral training program at the Chemistry-Biology Interface involves 31 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). The mission of the CBITG at the University of Minnesota is to provide a diverse cadre of students with the skills necessary to cross traditional boundaries and understand and conduct scientific research at the interface of chemistry and biology. This mission will be accomplished by achieving the following objectives: (i) Provide students with an interdisciplinary training experience at the interface of chemistry and biology through a combination of coursework involving classes from at least two departments and by a cross-training experience involving a coadvisor and a research experience of three months in the coadvisor's laboratory. (ii) Expose students to cutting-edge science at the interface of chemistry and biology through seminars focused on this type of interfacial science (Chemical Biology Colloquium) and by allowing them to organize their own symposium focused on the chemical biology interface. (iii) Enhance the communication skills of trainees by providing them with multiple opportunities to present their research including a presentation at a national or international conference. (iv) Educate students about the range of career opportunities available for scientists with training in this area. (v) Stimulate interest in our training program through te use of interviews with trainees, trainers and prominent scientists working at the chemistry/biology interface. (vi) Increase the diversity of scientists carrying out research at the chemistry and biology interface in our program through a combination of different outreach activities. Trainees will be involved in research themes that include: Biocatalysis and Biomolecular Design (Distefano, Kazlauskas, Lipscomb, Ohlendorf, Schmidt-Dannert, Seelig Wackett, Wagner, Wilmot), Therapeutic Agents (Aldrich, Amin, Bernlohr, Distefano, Georg, Harki, Haskell-Luevano, Hoye, Mansky, Tretyakova, Wagner, Xing), Chemistry of Disease (Aldrich, Arriaga, Bernlohr, Distefano, Harki, Haskell-Luevano, Mansky, Murphy, Pomerantz, Tretyakova, Wagner, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Wackett, Wilmot), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Pomerantz, Tretyakova, Thomas, Veglia). The research groups of the training faculty are all well supported and well equipped. This highly successful training program has been ongoing for 14 years. In this period, support is requested for 8 trainees each year of the program, each to be supported for a two-year period.